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From the same journal

Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach

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Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach. / Polack, Fiona A C; Droop, Alastair Philip.

In: Natural Computing, Vol. 14, No. 1, 03.2015, p. 63-82.

Research output: Contribution to journalArticlepeer-review

Harvard

Polack, FAC & Droop, AP 2015, 'Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach', Natural Computing, vol. 14, no. 1, pp. 63-82. https://doi.org/10.1007/s11047-014-9468-z

APA

Polack, F. A. C., & Droop, A. P. (2015). Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach. Natural Computing, 14(1), 63-82. https://doi.org/10.1007/s11047-014-9468-z

Vancouver

Polack FAC, Droop AP. Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach. Natural Computing. 2015 Mar;14(1):63-82. https://doi.org/10.1007/s11047-014-9468-z

Author

Polack, Fiona A C ; Droop, Alastair Philip. / Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach. In: Natural Computing. 2015 ; Vol. 14, No. 1. pp. 63-82.

Bibtex - Download

@article{0b3528f6ea8d49a789ca7854f86dd326,
title = "Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach",
abstract = "A collaboration between cancer biologists andacademic software engineers has been exploring thedevelopment of an agent-based simulator to inform andsupport work on the dynamics of cell proliferation in thestudy of prostate disorders. The research has influenced andbeen informed by the CoSMoS project. This paper presentsthe simulation project (which is not yet complete). Wereflect on the reality of following CoSMoS principles; wedescribe the domain exploration and show how softwaremodelling approaches (here, Petri nets, state diagrams) canbe used to express both biological and software models.We explore fitness for purpose and consider ways topresent a fitness argument. We consider issues in choosingsimulation media and mapping from domain modelsthrough to code. The implementation emphasis is ontraceability to support reuse and extension of the simulator,as well as demonstrable fitness for purpose. Initial work oncalibration is presented. We discuss the calibration results,that both support and challenge the design and assumptionscaptured in the domain modelling and developmentactivities.",
keywords = "Cell proliferation Agent-based simulation CoSMoS Modelling and simulation 1",
author = "Polack, {Fiona A C} and Droop, {Alastair Philip}",
year = "2015",
month = mar,
doi = "10.1007/s11047-014-9468-z",
language = "English",
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pages = "63--82",
journal = "Natural Computing",
issn = "1567-7818",
publisher = "Springer Netherlands",
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RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Principled Simulation of Cell Proliferation Dynamics using the CoSMoS Approach

AU - Polack, Fiona A C

AU - Droop, Alastair Philip

PY - 2015/3

Y1 - 2015/3

N2 - A collaboration between cancer biologists andacademic software engineers has been exploring thedevelopment of an agent-based simulator to inform andsupport work on the dynamics of cell proliferation in thestudy of prostate disorders. The research has influenced andbeen informed by the CoSMoS project. This paper presentsthe simulation project (which is not yet complete). Wereflect on the reality of following CoSMoS principles; wedescribe the domain exploration and show how softwaremodelling approaches (here, Petri nets, state diagrams) canbe used to express both biological and software models.We explore fitness for purpose and consider ways topresent a fitness argument. We consider issues in choosingsimulation media and mapping from domain modelsthrough to code. The implementation emphasis is ontraceability to support reuse and extension of the simulator,as well as demonstrable fitness for purpose. Initial work oncalibration is presented. We discuss the calibration results,that both support and challenge the design and assumptionscaptured in the domain modelling and developmentactivities.

AB - A collaboration between cancer biologists andacademic software engineers has been exploring thedevelopment of an agent-based simulator to inform andsupport work on the dynamics of cell proliferation in thestudy of prostate disorders. The research has influenced andbeen informed by the CoSMoS project. This paper presentsthe simulation project (which is not yet complete). Wereflect on the reality of following CoSMoS principles; wedescribe the domain exploration and show how softwaremodelling approaches (here, Petri nets, state diagrams) canbe used to express both biological and software models.We explore fitness for purpose and consider ways topresent a fitness argument. We consider issues in choosingsimulation media and mapping from domain modelsthrough to code. The implementation emphasis is ontraceability to support reuse and extension of the simulator,as well as demonstrable fitness for purpose. Initial work oncalibration is presented. We discuss the calibration results,that both support and challenge the design and assumptionscaptured in the domain modelling and developmentactivities.

KW - Cell proliferation Agent-based simulation CoSMoS Modelling and simulation 1

U2 - 10.1007/s11047-014-9468-z

DO - 10.1007/s11047-014-9468-z

M3 - Article

VL - 14

SP - 63

EP - 82

JO - Natural Computing

JF - Natural Computing

SN - 1567-7818

IS - 1

ER -