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Probing bacterial uptake of glycosylated ciprofloxacin conjugates

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Probing bacterial uptake of glycosylated ciprofloxacin conjugates. / Milner, Stephen J; Carrick, Christopher T; Kerr, Kevin G; Snelling, Anna M; Thomas, Gavin H; Duhme-Klair, Anne-Kathrin; Routledge, Anne.

In: Chembiochem, Vol. 15, No. 3, 10.02.2014, p. 466-471.

Research output: Contribution to journalArticlepeer-review

Harvard

Milner, SJ, Carrick, CT, Kerr, KG, Snelling, AM, Thomas, GH, Duhme-Klair, A-K & Routledge, A 2014, 'Probing bacterial uptake of glycosylated ciprofloxacin conjugates', Chembiochem, vol. 15, no. 3, pp. 466-471. https://doi.org/10.1002/cbic.201300512

APA

Milner, S. J., Carrick, C. T., Kerr, K. G., Snelling, A. M., Thomas, G. H., Duhme-Klair, A-K., & Routledge, A. (2014). Probing bacterial uptake of glycosylated ciprofloxacin conjugates. Chembiochem, 15(3), 466-471. https://doi.org/10.1002/cbic.201300512

Vancouver

Milner SJ, Carrick CT, Kerr KG, Snelling AM, Thomas GH, Duhme-Klair A-K et al. Probing bacterial uptake of glycosylated ciprofloxacin conjugates. Chembiochem. 2014 Feb 10;15(3):466-471. https://doi.org/10.1002/cbic.201300512

Author

Milner, Stephen J ; Carrick, Christopher T ; Kerr, Kevin G ; Snelling, Anna M ; Thomas, Gavin H ; Duhme-Klair, Anne-Kathrin ; Routledge, Anne. / Probing bacterial uptake of glycosylated ciprofloxacin conjugates. In: Chembiochem. 2014 ; Vol. 15, No. 3. pp. 466-471.

Bibtex - Download

@article{c83e014eb6f14c57b5e2dabc64f80a20,
title = "Probing bacterial uptake of glycosylated ciprofloxacin conjugates",
abstract = "Mono- and disaccharide-functionalised conjugates of the fluoroquinolone antibiotic ciprofloxacin have been synthesised and used as chemical probes of the bacterial uptake of glycosylated ciprofloxacin. Their antimicrobial activities against a panel of clinically relevant bacteria were determined: the ability of these conjugates to inhibit their target DNA gyrase and to be transported into the bacteria was assessed by using in vivo and in vitro assays. The data suggest a lack of active uptake through sugar transporters and that although the addition of monosaccharides is compatible with the inhibition of DNA gyrase, the addition of a disaccharide results in a significant decrease in antimicrobial activity.",
author = "Milner, {Stephen J} and Carrick, {Christopher T} and Kerr, {Kevin G} and Snelling, {Anna M} and Thomas, {Gavin H} and Anne-Kathrin Duhme-Klair and Anne Routledge",
note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2014",
month = feb,
day = "10",
doi = "10.1002/cbic.201300512",
language = "English",
volume = "15",
pages = "466--471",
journal = "Chembiochem",
issn = "1439-4227",
publisher = "Wiley-VCH Verlag",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Probing bacterial uptake of glycosylated ciprofloxacin conjugates

AU - Milner, Stephen J

AU - Carrick, Christopher T

AU - Kerr, Kevin G

AU - Snelling, Anna M

AU - Thomas, Gavin H

AU - Duhme-Klair, Anne-Kathrin

AU - Routledge, Anne

N1 - Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2014/2/10

Y1 - 2014/2/10

N2 - Mono- and disaccharide-functionalised conjugates of the fluoroquinolone antibiotic ciprofloxacin have been synthesised and used as chemical probes of the bacterial uptake of glycosylated ciprofloxacin. Their antimicrobial activities against a panel of clinically relevant bacteria were determined: the ability of these conjugates to inhibit their target DNA gyrase and to be transported into the bacteria was assessed by using in vivo and in vitro assays. The data suggest a lack of active uptake through sugar transporters and that although the addition of monosaccharides is compatible with the inhibition of DNA gyrase, the addition of a disaccharide results in a significant decrease in antimicrobial activity.

AB - Mono- and disaccharide-functionalised conjugates of the fluoroquinolone antibiotic ciprofloxacin have been synthesised and used as chemical probes of the bacterial uptake of glycosylated ciprofloxacin. Their antimicrobial activities against a panel of clinically relevant bacteria were determined: the ability of these conjugates to inhibit their target DNA gyrase and to be transported into the bacteria was assessed by using in vivo and in vitro assays. The data suggest a lack of active uptake through sugar transporters and that although the addition of monosaccharides is compatible with the inhibition of DNA gyrase, the addition of a disaccharide results in a significant decrease in antimicrobial activity.

U2 - 10.1002/cbic.201300512

DO - 10.1002/cbic.201300512

M3 - Article

C2 - 24449436

VL - 15

SP - 466

EP - 471

JO - Chembiochem

JF - Chembiochem

SN - 1439-4227

IS - 3

ER -