Probing linker design in citric acid-ciprofloxacin conjugates

Stephen J. Milner, Anna M. Snelling, Kevin G. Kerr, Ahmad Abd-El-Aziz, Gavin H. Thomas, Roderick E. Hubbard, Anne Routledge*, Anne Kathrin Duhme-Klair

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling. © 2014 Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)4499-4505
Number of pages7
JournalBioorganic & Medicinal Chemistry
Issue number16
Early online date15 Apr 2014
Publication statusPublished - 15 Aug 2014

Bibliographical note

Copyright © 2014 Elsevier Ltd. All rights reserved.


  • Antibiotic
  • Citrate
  • Computational modelling
  • Siderophore

Cite this