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Probing linker design in citric acid-ciprofloxacin conjugates

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JournalBioorganic & Medicinal Chemistry
DateE-pub ahead of print - 15 Apr 2014
DatePublished (current) - 15 Aug 2014
Issue number16
Volume22
Number of pages7
Pages (from-to)4499-4505
Early online date15/04/14
Original languageEnglish

Abstract

A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling. © 2014 Published by Elsevier Ltd. All rights reserved.

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Copyright © 2014 Elsevier Ltd. All rights reserved.

    Research areas

  • Antibiotic, Citrate, Computational modelling, Siderophore

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