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Probing linker design in citric acid-ciprofloxacin conjugates

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Probing linker design in citric acid-ciprofloxacin conjugates. / Milner, Stephen J.; Snelling, Anna M.; Kerr, Kevin G.; Abd-El-Aziz, Ahmad; Thomas, Gavin H.; Hubbard, Roderick E.; Routledge, Anne; Duhme-Klair, Anne Kathrin.

In: Bioorganic & Medicinal Chemistry, Vol. 22, No. 16, 15.08.2014, p. 4499-4505.

Research output: Contribution to journalArticle

Harvard

Milner, SJ, Snelling, AM, Kerr, KG, Abd-El-Aziz, A, Thomas, GH, Hubbard, RE, Routledge, A & Duhme-Klair, AK 2014, 'Probing linker design in citric acid-ciprofloxacin conjugates', Bioorganic & Medicinal Chemistry, vol. 22, no. 16, pp. 4499-4505. https://doi.org/10.1016/j.bmc.2014.04.009

APA

Milner, S. J., Snelling, A. M., Kerr, K. G., Abd-El-Aziz, A., Thomas, G. H., Hubbard, R. E., ... Duhme-Klair, A. K. (2014). Probing linker design in citric acid-ciprofloxacin conjugates. Bioorganic & Medicinal Chemistry, 22(16), 4499-4505. https://doi.org/10.1016/j.bmc.2014.04.009

Vancouver

Milner SJ, Snelling AM, Kerr KG, Abd-El-Aziz A, Thomas GH, Hubbard RE et al. Probing linker design in citric acid-ciprofloxacin conjugates. Bioorganic & Medicinal Chemistry. 2014 Aug 15;22(16):4499-4505. https://doi.org/10.1016/j.bmc.2014.04.009

Author

Milner, Stephen J. ; Snelling, Anna M. ; Kerr, Kevin G. ; Abd-El-Aziz, Ahmad ; Thomas, Gavin H. ; Hubbard, Roderick E. ; Routledge, Anne ; Duhme-Klair, Anne Kathrin. / Probing linker design in citric acid-ciprofloxacin conjugates. In: Bioorganic & Medicinal Chemistry. 2014 ; Vol. 22, No. 16. pp. 4499-4505.

Bibtex - Download

@article{828abd2ef7fb4513b993ef229fdbf9bf,
title = "Probing linker design in citric acid-ciprofloxacin conjugates",
abstract = "A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling. {\circledC} 2014 Published by Elsevier Ltd. All rights reserved.",
keywords = "Antibiotic, Citrate, Computational modelling, Siderophore",
author = "Milner, {Stephen J.} and Snelling, {Anna M.} and Kerr, {Kevin G.} and Ahmad Abd-El-Aziz and Thomas, {Gavin H.} and Hubbard, {Roderick E.} and Anne Routledge and Duhme-Klair, {Anne Kathrin}",
note = "Copyright {\circledC} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = "8",
day = "15",
doi = "10.1016/j.bmc.2014.04.009",
language = "English",
volume = "22",
pages = "4499--4505",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "16",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Probing linker design in citric acid-ciprofloxacin conjugates

AU - Milner, Stephen J.

AU - Snelling, Anna M.

AU - Kerr, Kevin G.

AU - Abd-El-Aziz, Ahmad

AU - Thomas, Gavin H.

AU - Hubbard, Roderick E.

AU - Routledge, Anne

AU - Duhme-Klair, Anne Kathrin

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/8/15

Y1 - 2014/8/15

N2 - A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling. © 2014 Published by Elsevier Ltd. All rights reserved.

AB - A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling. © 2014 Published by Elsevier Ltd. All rights reserved.

KW - Antibiotic

KW - Citrate

KW - Computational modelling

KW - Siderophore

UR - http://www.scopus.com/inward/record.url?scp=84906220907&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2014.04.009

DO - 10.1016/j.bmc.2014.04.009

M3 - Article

VL - 22

SP - 4499

EP - 4505

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 16

ER -