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Problems caused by heterogeneity in meta-analysis: a case study of acupuncture trials

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Publication details

JournalAcupuncture in Medicine
DateE-pub ahead of print - 18 Oct 2013
DatePublished (current) - Feb 2014
Issue number1
Number of pages6
Pages (from-to)56-61
Early online date18/10/13
Original languageEnglish



To illustrate the pitfalls of using meta-analysis to combine estimates of effect in trials that are highly varied and have a high potential for bias.


We used a random-effects meta-analysis to pool the results of 51 sham-controlled acupuncture trials of chronic pain published in English before 2008 and explored the heterogeneity using meta-regression. We repeated the process on a subset of these trials that used a visually credible non-penetrating sham device as control (N = 12).


In both analyses there were high levels of heterogeneity and many studies were at risk from potential bias. The heterogeneity was not explained by meta-regression.


Trials of interventions that have high potential for bias, such as many in the acupuncture literature, do not meet the assumptions of the statistical procedure that underlie random-effects meta-analysis. Even in the absence of bias, heterogeneity in meta-analyses is not accounted for by the CIs around the pooled estimate.

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