Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EU-MDS Registry

L. Swart, W Thomas Johnston, Alexandra Smith, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Eva Hellström-Lindberg, Guillermo Sanz, Reinhard Stauder, Luca Malcovati, Ulrich Germing, Gerwin Huls, Mette Holm, Moshe Mittelman, K. Madry, A. Tatic, Antonio Almeida, Aleksandar Savic, Sophie Park, Theo Witte

Research output: Contribution to journalMeeting abstractpeer-review


Background The outcome of lower-risk MDS patients with red blood cell transfusions (RBCT) dependency is inferior to that of RBCT independent patients, but whether the intensity of RBCT is important for prognosis is unknown. The EUMDS Registry is a non-interventional, observational longitudinal study enrolling patients with lower-risk MDS from 142 sites in 17 countries as described elsewhere (1). The EUMDS registry has accrued 1,902 patients as of July 21, 2015. We hypothesized that RBCT intensity is an independent prognostic factor for survival. Methods We first assessed the impact of RBCT intensity in the first year post-diagnosis (1yrPD) on progression-free survival among the 1034 patients who survived at least 1yrPD and had potential for a further year of follow-up. Secondly, we developed a longitudinal model of platelet counts throughout follow-up for 1660 patients in the registry with potential for at least one year follow-up. Results Among the 1034 patients, 323 patients had died: 67 after progression to higher-risk MDS/AML and 256 without progression. A further 41 surviving patients had progressed to AML. The overall 5-year survival was 52%. In a proportional hazards regression model (Table), the risk of death or progression increased in a non-linear fashion with age at diagnosis (p
Original languageEnglish
Article number637
Pages (from-to)1677
Number of pages1
Issue number23
Publication statusPublished - 3 Dec 2015
Event57th ASH Annual Meeting & Exposition - Orlando, Florida, United States
Duration: 5 Dec 20158 Dec 2015
Conference number: 57

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