Abstract
β-Lactams were prepared from imines and aryl-substituted acetic acids using T3P as an activating agent. In most cases, good to excellent yields were obtained (up to 93%) and the trans-β-lactam was the exclusive or major diastereoisomer (confirmed through analysis of <sup>1</sup>H NMR coupling constants and by X-ray crystallography).
Original language | English |
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Pages (from-to) | 3113-3116 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 23 |
Early online date | 8 Jan 2015 |
DOIs | |
Publication status | Published - 3 Jun 2015 |
Keywords
- Direct imine acylation (DIA)
- Imines
- N-Acyliminium ions
- T3P
- β-Lactams