Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids

Graeme Coulthard*, William P. Unsworth, Richard J. K. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


β-Lactams were prepared from imines and aryl-substituted acetic acids using T3P as an activating agent. In most cases, good to excellent yields were obtained (up to 93%) and the trans-β-lactam was the exclusive or major diastereoisomer (confirmed through analysis of <sup>1</sup>H NMR coupling constants and by X-ray crystallography).

Original languageEnglish
Pages (from-to)3113-3116
Number of pages4
JournalTetrahedron Letters
Issue number23
Early online date8 Jan 2015
Publication statusPublished - 3 Jun 2015


  • Direct imine acylation (DIA)
  • Imines
  • N-Acyliminium ions
  • T3P
  • β-Lactams

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