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Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids

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Publication details

JournalTetrahedron Letters
DateE-pub ahead of print - 8 Jan 2015
DatePublished (current) - 3 Jun 2015
Issue number23
Number of pages4
Pages (from-to)3113-3116
Early online date8/01/15
Original languageEnglish


β-Lactams were prepared from imines and aryl-substituted acetic acids using T3P as an activating agent. In most cases, good to excellent yields were obtained (up to 93%) and the trans-β-lactam was the exclusive or major diastereoisomer (confirmed through analysis of <sup>1</sup>H NMR coupling constants and by X-ray crystallography).

    Research areas

  • Direct imine acylation (DIA), Imines, N-Acyliminium ions, T3P, β-Lactams

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