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Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids
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| Journal | Tetrahedron Letters |
|---|---|
| Date | E-pub ahead of print - 8 Jan 2015 |
| Date | Published (current) - 3 Jun 2015 |
| Issue number | 23 |
| Volume | 56 |
| Number of pages | 4 |
| Pages (from-to) | 3113-3116 |
| Early online date | 8/01/15 |
| Original language | English |
Abstract
β-Lactams were prepared from imines and aryl-substituted acetic acids using T3P as an activating agent. In most cases, good to excellent yields were obtained (up to 93%) and the trans-β-lactam was the exclusive or major diastereoisomer (confirmed through analysis of <sup>1</sup>H NMR coupling constants and by X-ray crystallography).
- Direct imine acylation (DIA), Imines, N-Acyliminium ions, T3P, β-Lactams
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