Prostate cancer stem cells

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Despite the discovery over 60 years ago by Huggins and Hodges [1] that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalJournal of Pathology
Volume217
Issue number2
DOIs
Publication statusPublished - Jan 2009

Keywords

  • prostate
  • stem cells
  • neoplasia
  • ANDROGEN RECEPTOR GENE
  • SELF-RENEWAL
  • EPITHELIAL-CELLS
  • DNA-DAMAGE
  • BASAL-CELL
  • TUMOR PROGRESSION
  • MOUSE PROSTATE
  • EXPRESSION
  • REPAIR
  • CARCINOMA

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