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Prostate cancer stem cells: Are they androgen-responsive?

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Prostate cancer stem cells : Are they androgen-responsive? / Oldridge, Emma E; Pellacani, Davide; Collins, Anne T; Maitland, Norman J.

In: Molecular and cellular endocrinology, Vol. 2, No. 1-2, 05.09.2011, p. 47-61.

Research output: Contribution to journalArticle

Harvard

Oldridge, EE, Pellacani, D, Collins, AT & Maitland, NJ 2011, 'Prostate cancer stem cells: Are they androgen-responsive?', Molecular and cellular endocrinology, vol. 2, no. 1-2, pp. 47-61. https://doi.org/10.1016/j.mce.2011.07.008

APA

Oldridge, E. E., Pellacani, D., Collins, A. T., & Maitland, N. J. (2011). Prostate cancer stem cells: Are they androgen-responsive? Molecular and cellular endocrinology, 2(1-2), 47-61. https://doi.org/10.1016/j.mce.2011.07.008

Vancouver

Oldridge EE, Pellacani D, Collins AT, Maitland NJ. Prostate cancer stem cells: Are they androgen-responsive? Molecular and cellular endocrinology. 2011 Sep 5;2(1-2):47-61. https://doi.org/10.1016/j.mce.2011.07.008

Author

Oldridge, Emma E ; Pellacani, Davide ; Collins, Anne T ; Maitland, Norman J. / Prostate cancer stem cells : Are they androgen-responsive?. In: Molecular and cellular endocrinology. 2011 ; Vol. 2, No. 1-2. pp. 47-61.

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@article{0ae9394268a84de7a03be4f813f474f0,
title = "Prostate cancer stem cells: Are they androgen-responsive?",
abstract = "The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-responsive, but androgen-independent, basal compartment in which stem cells reside. Basal and luminal cells are linked in a hierarchical pathway, which most probably exists as a continuum with different stages of phenotypic change. Prostate cancer is also characterised by heterogeneity, which is reflected in its response to treatment. The putative androgen receptor negative cancer stem cell (CSC) is likely to form a resistant core after most androgen-based therapies, contributing to the evolution of castration-resistant disease. The development of CSC-targeted therapies is now of crucial importance and identifying the phenotypic differences between CSCs and both their progeny will be key in this process.",
author = "Oldridge, {Emma E} and Davide Pellacani and Collins, {Anne T} and Maitland, {Norman J}",
note = "Copyright {\circledC} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2011",
month = "9",
day = "5",
doi = "10.1016/j.mce.2011.07.008",
language = "English",
volume = "2",
pages = "47--61",
journal = "Molecular and cellular endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Prostate cancer stem cells

T2 - Molecular and cellular endocrinology

AU - Oldridge, Emma E

AU - Pellacani, Davide

AU - Collins, Anne T

AU - Maitland, Norman J

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2011/9/5

Y1 - 2011/9/5

N2 - The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-responsive, but androgen-independent, basal compartment in which stem cells reside. Basal and luminal cells are linked in a hierarchical pathway, which most probably exists as a continuum with different stages of phenotypic change. Prostate cancer is also characterised by heterogeneity, which is reflected in its response to treatment. The putative androgen receptor negative cancer stem cell (CSC) is likely to form a resistant core after most androgen-based therapies, contributing to the evolution of castration-resistant disease. The development of CSC-targeted therapies is now of crucial importance and identifying the phenotypic differences between CSCs and both their progeny will be key in this process.

AB - The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-responsive, but androgen-independent, basal compartment in which stem cells reside. Basal and luminal cells are linked in a hierarchical pathway, which most probably exists as a continuum with different stages of phenotypic change. Prostate cancer is also characterised by heterogeneity, which is reflected in its response to treatment. The putative androgen receptor negative cancer stem cell (CSC) is likely to form a resistant core after most androgen-based therapies, contributing to the evolution of castration-resistant disease. The development of CSC-targeted therapies is now of crucial importance and identifying the phenotypic differences between CSCs and both their progeny will be key in this process.

UR - http://www.scopus.com/inward/record.url?scp=84864024116&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2011.07.008

DO - 10.1016/j.mce.2011.07.008

M3 - Article

VL - 2

SP - 47

EP - 61

JO - Molecular and cellular endocrinology

JF - Molecular and cellular endocrinology

SN - 0303-7207

IS - 1-2

ER -