By the same authors

From the same journal

Prostate cancer stem cells

Research output: Contribution to journalLiterature review

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalJournal of Pathology
DatePublished - Jan 2009
Issue number2
Volume217
Number of pages8
Pages (from-to)299-306
Original languageEnglish

Abstract

Despite the discovery over 60 years ago by Huggins and Hodges [1] that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

    Research areas

  • prostate, stem cells, neoplasia, ANDROGEN RECEPTOR GENE, SELF-RENEWAL, EPITHELIAL-CELLS, DNA-DAMAGE, BASAL-CELL, TUMOR PROGRESSION, MOUSE PROSTATE, EXPRESSION, REPAIR, CARCINOMA

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations