By the same authors

From the same journal

Protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III

Research output: Contribution to journalArticlepeer-review

Author(s)

  • R A Holton
  • Z M Zhang
  • P A Clarke
  • H Nadizadeh
  • D J Procter

Department/unit(s)

Publication details

JournalTetrahedron Letters
DatePublished - 7 May 1998
Issue number19
Volume39
Number of pages4
Pages (from-to)2883-2886
Original languageEnglish

Abstract

New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward. (C) 1998 Elsevier Science Ltd. All rights reserved.

    Research areas

  • acylation, lanthanides, protecting groups, taxoid, TAXOL, HEMISYNTHESIS, EFFICIENT

Research outputs

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations