Protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III

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Research output: Contribution to journal › Article › peer-review

Author(s)

R A Holton
Z M Zhang
P A Clarke
H Nadizadeh
D J Procter

Department/unit(s)

Chemistry

Publication details

Journal	Tetrahedron Letters
Date	Published - 7 May 1998
Issue number	19
Volume	39
Number of pages	4
Pages (from-to)	2883-2886
Original language	English

Abstract

New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward. (C) 1998 Elsevier Science Ltd. All rights reserved.