Protein engineering 20 years on

By the same authors

Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations
Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J. & Fascione, M. A., 7 Jul 2018
Article in Chemical Science
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 1 Jun 2018
Article in Nature Chemistry
Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase
Goncalves, V., Brannigan, J. A., Laporte, A., Bell, A. S., Roberts, S. M., Wilkinson, A. J., Leatherbarrow, R. J. & Tate, E. W., 2017
Article in MedChemComm
N-myristoyltransferase as a Target for Drug Discovery in Malaria
Brannigan, J. A. & Wilkinson, A. J., 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Muller, S., Cerdan, R. & Radulescu, O. (eds.). 1 ed. Weinheim, Germany: Wiley-VCH, Vol. 7. p. 275-294 20 p. 11. (Drug Discovery in Infectious Diseases; vol. 7).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Structure mediation in substrate binding and post-translational processing of penicillin acylases: Information from mutant structures of Kluyvera citrophila penicillin G acylase
Chand, D., Varshney, N., Ramasamy, S., Panigrahi, P., Brannigan, J. A., Wilkinson, A. J. & Suresh, C. G., 1 Oct 2015
Article in Protein Science

From the same journal

Lysosomes: fusion and function
Luzio, J. P., Pryor, P. R. & Bright, N. A., Aug 2007
Article in Nature reviews. Molecular cell biology
Thinking quantitatively about transcriptional regulation
Greive, S. J. & von Hippel, P. H., Mar 2005
Review article in Nature reviews. Molecular cell biology
RNA polymerases I and III, growth control and cancer.
White, R. J., 2005
Article in Nature reviews. Molecular cell biology

Research output: Contribution to journal › Literature review

Published copy (DOI)

10.1038/nrm975

Author(s)

Department/unit(s)

Chemistry

Publication details

Journal	Nature reviews. Molecular cell biology
Date	Published - Dec 2002
Issue number	12
Volume	3
Number of pages	8
Pages (from-to)	964-970
Original language	English

Abstract

It is 20 years since site-directed mutagenesis was first used to modify the active site of an enzyme of known structure and mechanism. Since then, this method has contributed far-reaching insights into catalysis, specificity, stability and folding of proteins. Engineered proteins are now being used in industry and for the improved treatment of human disease.

Research areas

SITE-DIRECTED MUTAGENESIS, TRANSFER-RNA-SYNTHETASE, LACTATE-DEHYDROGENASE FRAMEWORK, TRANSITION-STATE, IN-VITRO, SUBSTRATE-SPECIFICITY, MOLECULAR EVOLUTION, BLOOD SUBSTITUTES, ESCHERICHIA-COLI, ENZYME CATALYSIS

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