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Protein engineering 20 years on

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JournalNature reviews. Molecular cell biology
DatePublished - Dec 2002
Issue number12
Volume3
Number of pages8
Pages (from-to)964-970
Original languageEnglish

Abstract

It is 20 years since site-directed mutagenesis was first used to modify the active site of an enzyme of known structure and mechanism. Since then, this method has contributed far-reaching insights into catalysis, specificity, stability and folding of proteins. Engineered proteins are now being used in industry and for the improved treatment of human disease.

    Research areas

  • SITE-DIRECTED MUTAGENESIS, TRANSFER-RNA-SYNTHETASE, LACTATE-DEHYDROGENASE FRAMEWORK, TRANSITION-STATE, IN-VITRO, SUBSTRATE-SPECIFICITY, MOLECULAR EVOLUTION, BLOOD SUBSTITUTES, ESCHERICHIA-COLI, ENZYME CATALYSIS

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