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Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain: I-WOTCH study

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Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain : I-WOTCH study. / Manchira Krishnan, Sheeja; Gc, Vijay Singh; Sandhu, Harbinder; Underwood, M.; Eldabe, Sam; Manca, Andrea; Iglesias Urrutia, Cynthia Paola.

In: BMJ Open, Vol. 10, 20.11.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Manchira Krishnan, S, Gc, VS, Sandhu, H, Underwood, M, Eldabe, S, Manca, A & Iglesias Urrutia, CP 2020, 'Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain: I-WOTCH study', BMJ Open, vol. 10. https://doi.org/10.1136/bmjopen-2020-037243

APA

Manchira Krishnan, S., Gc, V. S., Sandhu, H., Underwood, M., Eldabe, S., Manca, A., & Iglesias Urrutia, C. P. (2020). Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain: I-WOTCH study. BMJ Open, 10. https://doi.org/10.1136/bmjopen-2020-037243

Vancouver

Manchira Krishnan S, Gc VS, Sandhu H, Underwood M, Eldabe S, Manca A et al. Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain: I-WOTCH study. BMJ Open. 2020 Nov 20;10. https://doi.org/10.1136/bmjopen-2020-037243

Author

Manchira Krishnan, Sheeja ; Gc, Vijay Singh ; Sandhu, Harbinder ; Underwood, M. ; Eldabe, Sam ; Manca, Andrea ; Iglesias Urrutia, Cynthia Paola. / Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain : I-WOTCH study. In: BMJ Open. 2020 ; Vol. 10.

Bibtex - Download

@article{1f83b42f393142c0ab3f7be1fab27883,
title = "Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain: I-WOTCH study",
abstract = "Introduction: Over the last two decades, the use of opioids for the treatment of chronic pain in England has steadily increased despite lack of evidence of both long term effectiveness in pain relief and significant, well documented physical and mental adverse events. Guidelines recommend tapering when harms outweigh benefits, but the addictive nature of opioids hinders simple dose reduction strategies. Improving the Wellbeing of people with Opioid Treated CHronic pain (I WOTCH) trial tests a multicomponent self-management intervention aimed to help patients with chronic non malignant pain taper opioid doses. This paper outlines the methods to be used for the economic analysis of the I WOTCH intervention compared to the best usual care. Methods and analysis: Economic evaluation alongside the I WOTCH study, prospectively designed to identify, measure, and value key healthcare resource use and outcomes arising from the treatment strategies being compared. A within trial cost consequences analysis and a model based long-term cost effectiveness analysis will be conducted from the National Health Service and Personal Social Service perspective in England. The former will quantify key parameters to populate a Markov model designed to estimate the long-term cost and quality adjusted life years of the I-WOTCH programme against best usual care. Regression equations will be used to estimate parameters such as transition probabilities, utilities, and costs associated with the model{\textquoteright}s states and events. Probabilistic sensitivity analysis will be used to assess the impact of parameter uncertainty onto the predicted costs and health outcomes, and the resulting value for money assessment of the I-WOTCH programme. Ethics and dissemination: Full ethics approval was granted by Yorkshire & The Humber – South Yorkshire Research Ethics Committee on September 13th, 2016 (16/YH/0325). Current protocol: version 1.7, date 31 July 2019. Findings will be disseminated in peer reviewed journals, scientific conferences, newsletters, and websites. Registration details: International Standard Randomised Controlled Trial Number: 49470934 (6 Feb 2017). ",
author = "{Manchira Krishnan}, Sheeja and Gc, {Vijay Singh} and Harbinder Sandhu and M. Underwood and Sam Eldabe and Andrea Manca and {Iglesias Urrutia}, {Cynthia Paola}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2020.",
year = "2020",
month = nov,
day = "20",
doi = "10.1136/bmjopen-2020-037243",
language = "English",
volume = "10",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "British Medical Journal Publishing Group",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Protocol for an economic analysis of the randomised controlled trial of improving the wellbeing of people with opioid treated chronic pain

T2 - I-WOTCH study

AU - Manchira Krishnan, Sheeja

AU - Gc, Vijay Singh

AU - Sandhu, Harbinder

AU - Underwood, M.

AU - Eldabe, Sam

AU - Manca, Andrea

AU - Iglesias Urrutia, Cynthia Paola

N1 - © Author(s) (or their employer(s)) 2020.

PY - 2020/11/20

Y1 - 2020/11/20

N2 - Introduction: Over the last two decades, the use of opioids for the treatment of chronic pain in England has steadily increased despite lack of evidence of both long term effectiveness in pain relief and significant, well documented physical and mental adverse events. Guidelines recommend tapering when harms outweigh benefits, but the addictive nature of opioids hinders simple dose reduction strategies. Improving the Wellbeing of people with Opioid Treated CHronic pain (I WOTCH) trial tests a multicomponent self-management intervention aimed to help patients with chronic non malignant pain taper opioid doses. This paper outlines the methods to be used for the economic analysis of the I WOTCH intervention compared to the best usual care. Methods and analysis: Economic evaluation alongside the I WOTCH study, prospectively designed to identify, measure, and value key healthcare resource use and outcomes arising from the treatment strategies being compared. A within trial cost consequences analysis and a model based long-term cost effectiveness analysis will be conducted from the National Health Service and Personal Social Service perspective in England. The former will quantify key parameters to populate a Markov model designed to estimate the long-term cost and quality adjusted life years of the I-WOTCH programme against best usual care. Regression equations will be used to estimate parameters such as transition probabilities, utilities, and costs associated with the model’s states and events. Probabilistic sensitivity analysis will be used to assess the impact of parameter uncertainty onto the predicted costs and health outcomes, and the resulting value for money assessment of the I-WOTCH programme. Ethics and dissemination: Full ethics approval was granted by Yorkshire & The Humber – South Yorkshire Research Ethics Committee on September 13th, 2016 (16/YH/0325). Current protocol: version 1.7, date 31 July 2019. Findings will be disseminated in peer reviewed journals, scientific conferences, newsletters, and websites. Registration details: International Standard Randomised Controlled Trial Number: 49470934 (6 Feb 2017).

AB - Introduction: Over the last two decades, the use of opioids for the treatment of chronic pain in England has steadily increased despite lack of evidence of both long term effectiveness in pain relief and significant, well documented physical and mental adverse events. Guidelines recommend tapering when harms outweigh benefits, but the addictive nature of opioids hinders simple dose reduction strategies. Improving the Wellbeing of people with Opioid Treated CHronic pain (I WOTCH) trial tests a multicomponent self-management intervention aimed to help patients with chronic non malignant pain taper opioid doses. This paper outlines the methods to be used for the economic analysis of the I WOTCH intervention compared to the best usual care. Methods and analysis: Economic evaluation alongside the I WOTCH study, prospectively designed to identify, measure, and value key healthcare resource use and outcomes arising from the treatment strategies being compared. A within trial cost consequences analysis and a model based long-term cost effectiveness analysis will be conducted from the National Health Service and Personal Social Service perspective in England. The former will quantify key parameters to populate a Markov model designed to estimate the long-term cost and quality adjusted life years of the I-WOTCH programme against best usual care. Regression equations will be used to estimate parameters such as transition probabilities, utilities, and costs associated with the model’s states and events. Probabilistic sensitivity analysis will be used to assess the impact of parameter uncertainty onto the predicted costs and health outcomes, and the resulting value for money assessment of the I-WOTCH programme. Ethics and dissemination: Full ethics approval was granted by Yorkshire & The Humber – South Yorkshire Research Ethics Committee on September 13th, 2016 (16/YH/0325). Current protocol: version 1.7, date 31 July 2019. Findings will be disseminated in peer reviewed journals, scientific conferences, newsletters, and websites. Registration details: International Standard Randomised Controlled Trial Number: 49470934 (6 Feb 2017).

U2 - 10.1136/bmjopen-2020-037243

DO - 10.1136/bmjopen-2020-037243

M3 - Article

VL - 10

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

ER -