Quinine catalysed asymmetric Michael additions in a sustainable solvent

José A. Castro-Osma, James W. Comerford, Samantha Heath, Oliver Jones, Maria Morcillo, Michael North*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Diethyl carbonate is shown to be a suitable, sustainable solvent in which to carry out quinine catalysed asymmetric Michael additions of malononitriles to enones. Both malonitrile and α-substituted malononitriles can be used as substrate and the results suggest that π-π stacking interactions between the (hetero)aromatic rings of the catalyst and substrates are important in determining the degree of asymmetric induction.

Original languageEnglish
Pages (from-to)3678-3685
Number of pages8
JournalRSC Advances
Issue number5
Publication statusPublished - 4 Dec 2014

Bibliographical note

© The Royal Society of Chemistry 2015. Self-archiving of publisher's PDF not supported by the publisher.

Cite this