Quorum machinery: Effect of the las system in rhl regulation of P. aeruginosa

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Publication details

Title of host publicationProceedings of the 8th SEAMS-UGM International Conference on Mathematics and Its Applications 2019
DatePublished - 19 Dec 2019
Number of pages12
PublisherAmerican Institute of Physics Inc.
EditorsHerni Utami, Fajar Adi Kusumo, Nanang Susyanto, Yeni Susanti
Original languageEnglish
ISBN (Electronic)9780735419438

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Quorum sensing (QS) describes a communication mechanism via signal molecules that allows colonies of bacteria to coordinate gene expression. The nature of the QS system depends very much on the species. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that has a highly complex QS system. The QS signalling system of P. aeruginosa is known to involve multiple control components, notably las, rhl and pqs systems. The QS signalling system of P. aeruginosa is responsive to two chemically different signal molecules, based on Homoserine-Lactones (HSLs) and 4-quinilines (4Qs). This paper focuses on the relation of the first two systems that manage Homoserine-Lactone (HSL) production since this is the main chemical signalling in P. aeruginosa that regulates many activities of bacteria, including symbiosis, virulence factors, motility, production of antibiotics, and formation of biofilm. The las and rhl system of P. aeruginosa do not act independently. Some gene expression that is regulated by rhl system is also controlled by the las system. Previous research has demonstrated that the las system can give rise to excitable pulse generation of signal molecule production. This paper examines the mechanism of how las and rhl systems act in tandem to generate sophisticated control on QS system of P. aeruginosa. Using analytic methods, it is shown how dynamics of the rhl system is affected by dynamics of the las system.

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© 2019 AIP Publishing LLC. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

    Research areas

  • las system, Pseudomonas aeruginosa, Quorum sensing, rhl system

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