@inproceedings{15ea6b2e7a464dfda1c3253989b4d5e3,
title = "Quorum machinery: Effect of the las system in rhl regulation of P. aeruginosa",
abstract = "Quorum sensing (QS) describes a communication mechanism via signal molecules that allows colonies of bacteria to coordinate gene expression. The nature of the QS system depends very much on the species. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that has a highly complex QS system. The QS signalling system of P. aeruginosa is known to involve multiple control components, notably las, rhl and pqs systems. The QS signalling system of P. aeruginosa is responsive to two chemically different signal molecules, based on Homoserine-Lactones (HSLs) and 4-quinilines (4Qs). This paper focuses on the relation of the first two systems that manage Homoserine-Lactone (HSL) production since this is the main chemical signalling in P. aeruginosa that regulates many activities of bacteria, including symbiosis, virulence factors, motility, production of antibiotics, and formation of biofilm. The las and rhl system of P. aeruginosa do not act independently. Some gene expression that is regulated by rhl system is also controlled by the las system. Previous research has demonstrated that the las system can give rise to excitable pulse generation of signal molecule production. This paper examines the mechanism of how las and rhl systems act in tandem to generate sophisticated control on QS system of P. aeruginosa. Using analytic methods, it is shown how dynamics of the rhl system is affected by dynamics of the las system.",
keywords = "las system, Pseudomonas aeruginosa, Quorum sensing, rhl system",
author = "Cicik Alfiniyah and Bees, {Martin A.} and Wood, {A. Jamie}",
note = "{\textcopyright} 2019 AIP Publishing LLC. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details.; 8th SEAMS-UGM International Conference on Mathematics and Its Applications 2019: Deepening Mathematical Concepts for Wider Application through Multidisciplinary Research and Industries Collaborations ; Conference date: 29-07-2019 Through 01-08-2019",
year = "2019",
month = dec,
day = "19",
doi = "10.1063/1.5139147",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics",
pages = "1--12",
editor = "Herni Utami and Kusumo, {Fajar Adi} and Nanang Susyanto and Yeni Susanti",
booktitle = "Proceedings of the 8th SEAMS-UGM International Conference on Mathematics and Its Applications 2019",
address = "United States",
}