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Racemization of aspartic acid in human proteins

Research output: Contribution to journalLiterature review

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JournalAgeing Research Reviews
DatePublished - Feb 2002
Issue number1
Volume1
Number of pages17
Pages (from-to)43-59
Original languageEnglish

Abstract

Aspartic acid racemization (AAR) represents one of the major types of non-enzymatic covalent modification that leads to an age-dependent accumulation of abnormal protein in numerous human tissues. In vivo racemization is an autonomic process during the 'natural' ageing of proteins, and correlates with the age of long-lived proteins. Consequently AAR can be used as molecular indicator of protein ageing as well as for the identification of permanent proteins that age with the human organism. Although long-living, structural proteins are mainly affected, AAR may be significant on a time scale also relevant to enzymes and signaling proteins. It may result in a loss of protein function due to proteolysis or due to changes in the molecular structure. In vivo racemization may also increase in pathological conditions. AAR has already been discussed as a relevant pathophysiological factor in the pathogenesis of diseases of old age such as atherosclerosis, lung emphysema, presbyopia, cataract, degenerative diseases of cartilage and cerebral age-related dysfunctions. Although the details of the biological consequences of AAR have to be further elucidated, it is evident that AAR plays a role in the molecular biology of ageing. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    Research areas

  • aspartic acid, racemization, review, succinimide, deamidation, collagen, ALPHA-A-CRYSTALLIN, MYELIN BASIC-PROTEIN, HUMAN ARTICULAR-CARTILAGE, PAIRED HELICAL FILAMENTS, HUMAN CORTICAL BONE, DAMAGED PROTEINS, ASPARAGINYL RESIDUES, IN-VITRO, REPAIR METHYLTRANSFERASE, 3-DIMENSIONAL STRUCTURE

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