Rapidly regulated genes are intron poor

Daniel C. Jeffares*, Christopher J. Penkett, Jürg Bähler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalTrends in Genetics
Issue number8
Publication statusPublished - Aug 2008

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