Rapidly regulated genes are intron poor

Daniel C. Jeffares; Christopher J. Penkett; Jürg Bähler

doi:10.1016/j.tig.2008.05.006

Rapidly regulated genes are intron poor

Daniel C. Jeffares^*, Christopher J. Penkett, Jürg Bähler

^*Corresponding author for this work

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	Trends in Genetics
Volume	24
Issue number	8
DOIs	https://doi.org/10.1016/j.tig.2008.05.006
Publication status	Published - Aug 2008

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10.1016/j.tig.2008.05.006

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title = "Rapidly regulated genes are intron poor",

abstract = "We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.",

author = "Jeffares, {Daniel C.} and Penkett, {Christopher J.} and J{\"u}rg B{\"a}hler",

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AU - Penkett, Christopher J.

AU - Bähler, Jürg

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N2 - We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.

AB - We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.

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U2 - 10.1016/j.tig.2008.05.006

DO - 10.1016/j.tig.2008.05.006

M3 - Article

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AN - SCOPUS:48949115109

SN - 0168-9525

VL - 24

SP - 375

EP - 378

JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

Rapidly regulated genes are intron poor

Abstract

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