By the same authors

Rational Design of Activity-Based Retaining β-Exoglucosidase Probes

Research output: Chapter in Book/Report/Conference proceedingChapter

Standard

Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. / Li, Kah-Yee; Kallemeijn, Wouter W.; Jiang, Jianbing; Walvoort, Marthe; Willems, Lianne; Beenakker, Thomas JM; Van Den Elst, Hans; Van Der Marel, Gijs; Codée, Jeroen D C; Aerts, Hans; Florea, Bogdan I.; Boot, Rolf G.; Witte, Martin; Overkleeft, Herman S.

Concepts and Case Studies in Chemical Biology. Wiley-Blackwell, 2014. p. 191-206.

Research output: Chapter in Book/Report/Conference proceedingChapter

Harvard

Li, K-Y, Kallemeijn, WW, Jiang, J, Walvoort, M, Willems, L, Beenakker, TJM, Van Den Elst, H, Van Der Marel, G, Codée, JDC, Aerts, H, Florea, BI, Boot, RG, Witte, M & Overkleeft, HS 2014, Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. in Concepts and Case Studies in Chemical Biology. Wiley-Blackwell, pp. 191-206. https://doi.org/10.1002/9783527687503.ch13

APA

Li, K-Y., Kallemeijn, W. W., Jiang, J., Walvoort, M., Willems, L., Beenakker, T. JM., Van Den Elst, H., Van Der Marel, G., Codée, J. D. C., Aerts, H., Florea, B. I., Boot, R. G., Witte, M., & Overkleeft, H. S. (2014). Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In Concepts and Case Studies in Chemical Biology (pp. 191-206). Wiley-Blackwell. https://doi.org/10.1002/9783527687503.ch13

Vancouver

Li K-Y, Kallemeijn WW, Jiang J, Walvoort M, Willems L, Beenakker TJM et al. Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In Concepts and Case Studies in Chemical Biology. Wiley-Blackwell. 2014. p. 191-206 https://doi.org/10.1002/9783527687503.ch13

Author

Li, Kah-Yee ; Kallemeijn, Wouter W. ; Jiang, Jianbing ; Walvoort, Marthe ; Willems, Lianne ; Beenakker, Thomas JM ; Van Den Elst, Hans ; Van Der Marel, Gijs ; Codée, Jeroen D C ; Aerts, Hans ; Florea, Bogdan I. ; Boot, Rolf G. ; Witte, Martin ; Overkleeft, Herman S. / Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. Concepts and Case Studies in Chemical Biology. Wiley-Blackwell, 2014. pp. 191-206

Bibtex - Download

@inbook{998a9a1c251041749391b6aa4a654c74,
title = "Rational Design of Activity-Based Retaining β-Exoglucosidase Probes",
abstract = "Activity-based probes (ABPs) have been developed for numerous serine hydrolases, cysteine proteases, and threonine hydrolases, but less frequently for other enzyme families. This chapter details the successful development and application of a number of activity-based retaining β-exoglucosidase probes. It discusses how, by rational design, suitable ABPs for retaining β-exoglucosidases can be designed. Mutations in the gene encoding glucosidase, beta, acid (GBA) can lead to partial malfunctioning of the enzyme, leading to accumulation of its substrate, glucosylceramide. This is in a nutshell the basis of the lysosomal storage disorder, Gaucher disease. The aziridine-based scaffold holds more promise, and as one can learn from Cazypedia, there are numerous retaining exoglycosidases that follow the general Koshland mechanism and that are, in principle, amenable to ABPP activity-based protein profiling using cyclitol aziridines emulating in configuration and substitution pattern the corresponding substrate glycosides.",
keywords = "Activity-based probes (ABPs), Activity-based retaining β-exoglucosidase probes, Cyclophellitol aziridine, GBA",
author = "Kah-Yee Li and Kallemeijn, {Wouter W.} and Jianbing Jiang and Marthe Walvoort and Lianne Willems and Beenakker, {Thomas JM} and {Van Den Elst}, Hans and {Van Der Marel}, Gijs and Cod{\'e}e, {Jeroen D C} and Hans Aerts and Florea, {Bogdan I.} and Boot, {Rolf G.} and Martin Witte and Overkleeft, {Herman S.}",
year = "2014",
month = oct,
day = "6",
doi = "10.1002/9783527687503.ch13",
language = "English",
isbn = "9783527336111",
pages = "191--206",
booktitle = "Concepts and Case Studies in Chemical Biology",
publisher = "Wiley-Blackwell",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Rational Design of Activity-Based Retaining β-Exoglucosidase Probes

AU - Li, Kah-Yee

AU - Kallemeijn, Wouter W.

AU - Jiang, Jianbing

AU - Walvoort, Marthe

AU - Willems, Lianne

AU - Beenakker, Thomas JM

AU - Van Den Elst, Hans

AU - Van Der Marel, Gijs

AU - Codée, Jeroen D C

AU - Aerts, Hans

AU - Florea, Bogdan I.

AU - Boot, Rolf G.

AU - Witte, Martin

AU - Overkleeft, Herman S.

PY - 2014/10/6

Y1 - 2014/10/6

N2 - Activity-based probes (ABPs) have been developed for numerous serine hydrolases, cysteine proteases, and threonine hydrolases, but less frequently for other enzyme families. This chapter details the successful development and application of a number of activity-based retaining β-exoglucosidase probes. It discusses how, by rational design, suitable ABPs for retaining β-exoglucosidases can be designed. Mutations in the gene encoding glucosidase, beta, acid (GBA) can lead to partial malfunctioning of the enzyme, leading to accumulation of its substrate, glucosylceramide. This is in a nutshell the basis of the lysosomal storage disorder, Gaucher disease. The aziridine-based scaffold holds more promise, and as one can learn from Cazypedia, there are numerous retaining exoglycosidases that follow the general Koshland mechanism and that are, in principle, amenable to ABPP activity-based protein profiling using cyclitol aziridines emulating in configuration and substitution pattern the corresponding substrate glycosides.

AB - Activity-based probes (ABPs) have been developed for numerous serine hydrolases, cysteine proteases, and threonine hydrolases, but less frequently for other enzyme families. This chapter details the successful development and application of a number of activity-based retaining β-exoglucosidase probes. It discusses how, by rational design, suitable ABPs for retaining β-exoglucosidases can be designed. Mutations in the gene encoding glucosidase, beta, acid (GBA) can lead to partial malfunctioning of the enzyme, leading to accumulation of its substrate, glucosylceramide. This is in a nutshell the basis of the lysosomal storage disorder, Gaucher disease. The aziridine-based scaffold holds more promise, and as one can learn from Cazypedia, there are numerous retaining exoglycosidases that follow the general Koshland mechanism and that are, in principle, amenable to ABPP activity-based protein profiling using cyclitol aziridines emulating in configuration and substitution pattern the corresponding substrate glycosides.

KW - Activity-based probes (ABPs)

KW - Activity-based retaining β-exoglucosidase probes

KW - Cyclophellitol aziridine

KW - GBA

UR - http://www.scopus.com/inward/record.url?scp=84926399717&partnerID=8YFLogxK

U2 - 10.1002/9783527687503.ch13

DO - 10.1002/9783527687503.ch13

M3 - Chapter

AN - SCOPUS:84926399717

SN - 9783527336111

SP - 191

EP - 206

BT - Concepts and Case Studies in Chemical Biology

PB - Wiley-Blackwell

ER -