Rational redox tuning of transition metal sites: Learning from superoxide reductase

Marius Horch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Using superoxide reductase as a model system, a computational approach reveals how histidine tautomerism tunes the redox properties of metalloenzymes to enable their catalytic function. Inspired by these experimentally inaccessible insights, non-canonical histidine congeners are introduced as new versatile tools for the rational engineering of biological transition metal sites.

Original languageEnglish
Pages (from-to)9148-9151
Number of pages4
JournalChemical Communications
Volume55
Issue number62
Early online date8 Jul 2019
DOIs
Publication statusE-pub ahead of print - 8 Jul 2019

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