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Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila

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Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila. / Oswald, Matthew Charles William; Brooks, Paul S.; Zwart, Maarten F.; Mukherjee, Amrita; West, Ryan John Hatcher; Giachello, Carlo; Morarach, Khomgrit; Baines, Richard A.; Sweeney, Sean; Landgraf, Matthias.

In: eLife, 12.12.2018.

Research output: Contribution to journalArticle

Harvard

Oswald, MCW, Brooks, PS, Zwart, MF, Mukherjee, A, West, RJH, Giachello, C, Morarach, K, Baines, RA, Sweeney, S & Landgraf, M 2018, 'Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila', eLife.

APA

Oswald, M. C. W., Brooks, P. S., Zwart, M. F., Mukherjee, A., West, R. J. H., Giachello, C., ... Landgraf, M. (2018). Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila. eLife.

Vancouver

Oswald MCW, Brooks PS, Zwart MF, Mukherjee A, West RJH, Giachello C et al. Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila. eLife. 2018 Dec 12.

Author

Oswald, Matthew Charles William ; Brooks, Paul S. ; Zwart, Maarten F. ; Mukherjee, Amrita ; West, Ryan John Hatcher ; Giachello, Carlo ; Morarach, Khomgrit ; Baines, Richard A. ; Sweeney, Sean ; Landgraf, Matthias. / Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila. In: eLife. 2018.

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@article{24f16d61ad834cdc9072ea14576700e0,
title = "Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila",
abstract = "Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1{\ss} as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.",
author = "Oswald, {Matthew Charles William} and Brooks, {Paul S.} and Zwart, {Maarten F.} and Amrita Mukherjee and West, {Ryan John Hatcher} and Carlo Giachello and Khomgrit Morarach and Baines, {Richard A.} and Sean Sweeney and Matthias Landgraf",
note = "{\circledC} 2018, Oswald et al.",
year = "2018",
month = "12",
day = "12",
language = "English",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila

AU - Oswald, Matthew Charles William

AU - Brooks, Paul S.

AU - Zwart, Maarten F.

AU - Mukherjee, Amrita

AU - West, Ryan John Hatcher

AU - Giachello, Carlo

AU - Morarach, Khomgrit

AU - Baines, Richard A.

AU - Sweeney, Sean

AU - Landgraf, Matthias

N1 - © 2018, Oswald et al.

PY - 2018/12/12

Y1 - 2018/12/12

N2 - Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1ß as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.

AB - Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1ß as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.

M3 - Article

JO - eLife

T2 - eLife

JF - eLife

SN - 2050-084X

ER -