Re‘COG’nition at the Golgi

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The conserved oligomeric Golgi (COG) complex coordinates retrograde vesicle transport within the Golgi. These vesicles maintain the distribution of glycosylation enzymes between the Golgi’s cisternae, and therefore COG is intimately involved in glycosylation homeostasis. Recent years have greatly enhanced our knowledge of COG’s composition, protein interactions, cellular function and most recently also its structure. The emergence of COG-dependent human glycosylation disorders gives particular relevance to these advances. The structural data have firmly placed COG in the family of multi-subunit tethering complexes that it shares with the exocyst, Dsl1 and Golgi-associated retrograde protein (GARP) complexes. Here, we review our knowledge of COG’s involvement in vesicle tethering at the Golgi. In particular, we consider what this knowledge may add to our molecular understanding of vesicle tethering and how it impacts on the fine tuning of Golgi function, most notably glycosylation.
Original languageEnglish
Pages (from-to)891-897
Number of pages7
Issue number7
Early online date27 Feb 2012
Publication statusPublished - Jul 2012


  • CATCHR family
  • COG
  • CDG
  • Golgi Apparatus

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