Re‘COG’nition at the Golgi

TY - JOUR

T1 - Re‘COG’nition at the Golgi

AU - Miller, Victoria

AU - Ungar, Dani

PY - 2012/7

Y1 - 2012/7

N2 - The conserved oligomeric Golgi (COG) complex coordinates retrograde vesicle transport within the Golgi. These vesicles maintain the distribution of glycosylation enzymes between the Golgi’s cisternae, and therefore COG is intimately involved in glycosylation homeostasis. Recent years have greatly enhanced our knowledge of COG’s composition, protein interactions, cellular function and most recently also its structure. The emergence of COG-dependent human glycosylation disorders gives particular relevance to these advances. The structural data have firmly placed COG in the family of multi-subunit tethering complexes that it shares with the exocyst, Dsl1 and Golgi-associated retrograde protein (GARP) complexes. Here, we review our knowledge of COG’s involvement in vesicle tethering at the Golgi. In particular, we consider what this knowledge may add to our molecular understanding of vesicle tethering and how it impacts on the fine tuning of Golgi function, most notably glycosylation.

AB - The conserved oligomeric Golgi (COG) complex coordinates retrograde vesicle transport within the Golgi. These vesicles maintain the distribution of glycosylation enzymes between the Golgi’s cisternae, and therefore COG is intimately involved in glycosylation homeostasis. Recent years have greatly enhanced our knowledge of COG’s composition, protein interactions, cellular function and most recently also its structure. The emergence of COG-dependent human glycosylation disorders gives particular relevance to these advances. The structural data have firmly placed COG in the family of multi-subunit tethering complexes that it shares with the exocyst, Dsl1 and Golgi-associated retrograde protein (GARP) complexes. Here, we review our knowledge of COG’s involvement in vesicle tethering at the Golgi. In particular, we consider what this knowledge may add to our molecular understanding of vesicle tethering and how it impacts on the fine tuning of Golgi function, most notably glycosylation.

KW - CATCHR family

KW - COG

KW - CDG

KW - MEMBRANE TRAFFICKING

KW - Golgi Apparatus

UR - http://www.scopus.com/inward/record.url?scp=84862259443&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0854.2012.01338.x

DO - 10.1111/j.1600-0854.2012.01338.x

M3 - Article

SN - 1398-9219

VL - 13

SP - 891

EP - 897

JO - Traffic

JF - Traffic

IS - 7

ER -