Recombination and Replication

Aisha H. Syeda, Michelle Hawkins, Peter McGlynn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA.

Original languageEnglish
Number of pages14
JournalCold Spring Harbor Perspectives in Biology
Issue number11
Publication statusPublished - 1 Nov 2014

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