Recombination and Replication

TY - JOUR

T1 - Recombination and Replication

AU - Syeda, Aisha H.

AU - Hawkins, Michelle

AU - McGlynn, Peter

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA.

AB - The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA.

UR - http://www.scopus.com/inward/record.url?scp=84905446435&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a016550

DO - 10.1101/cshperspect.a016550

M3 - Article

AN - SCOPUS:84905446435

SN - 1943-0264

VL - 6

JO - Cold Spring Harbor Perspectives in Biology

JF - Cold Spring Harbor Perspectives in Biology

IS - 11

ER -