Regioselective alkylation of a methylene group via meta-bridging of calix[4]arenes

Petr Slavík, Hana Dvořáková, Václav Eigner, Pavel Lhoták*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The meta-iodo derivative, fixed in the cone conformation, enables the gram-scale preparation of a meta-bridged calix[4]arene. This intermediate, possessing a fluorene moiety within the macrocyclic skeleton, can be regioselectively alkylated on the corresponding methylene bridge to form a unique substitution pattern in classical calixarene chemistry. This journal is

Original languageEnglish
Pages (from-to)10112-10114
Number of pages3
JournalChemical Communications
Issue number70
Publication statusPublished - 11 Sept 2014

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