Regulation of mesenchymal stem cell differentiation.

D. Cook; P. Genever

doi:10.1007/978-94-007-6621-1_12

Regulation of mesenchymal stem cell differentiation.

D. Cook, P. Genever

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

A population of multipotent stromal cells exists within bone marrow and other adult tissues, which is able to differentiate into different skeletal tissues such as bone, cartilage and fat. These cells are frequently referred to as mesenchymal stem cells (MSCs) and offer significant therapeutic potential, particularly in orthopaedic applications, but may also have broader roles in regenerative medicine, cancer treatment, as anti-inflammatories, immunosuppressives and vehicles for gene/protein therapy. Much attention has focused on understanding MSC biology and the regulation of differentiation to help realise these clinical aspirations. Here we review some of the key molecular determinants of MSC function, with an emphasis on transcription factor control and the cell-cell signalling pathways that regulate MSC differentiation. The source information comes from a range of different models, including isolated human MSC cultures, animal-derived MSC-like cell lines, animal models and skeletal developmental processes to provide a wide-angled overview of the important players in MSC biology and tri-lineage specification.

Original language	English
Pages (from-to)	213-229
Journal	Advances in experimental medicine and biology
Volume	786
DOIs	https://doi.org/10.1007/978-94-007-6621-1_12
Publication status	Published - 24 Apr 2013

Access to Document

10.1007/978-94-007-6621-1_12

Cite this

@article{21eb6cb9fbc94f0e8421315b7313039f,

title = "Regulation of mesenchymal stem cell differentiation.",

abstract = "A population of multipotent stromal cells exists within bone marrow and other adult tissues, which is able to differentiate into different skeletal tissues such as bone, cartilage and fat. These cells are frequently referred to as mesenchymal stem cells (MSCs) and offer significant therapeutic potential, particularly in orthopaedic applications, but may also have broader roles in regenerative medicine, cancer treatment, as anti-inflammatories, immunosuppressives and vehicles for gene/protein therapy. Much attention has focused on understanding MSC biology and the regulation of differentiation to help realise these clinical aspirations. Here we review some of the key molecular determinants of MSC function, with an emphasis on transcription factor control and the cell-cell signalling pathways that regulate MSC differentiation. The source information comes from a range of different models, including isolated human MSC cultures, animal-derived MSC-like cell lines, animal models and skeletal developmental processes to provide a wide-angled overview of the important players in MSC biology and tri-lineage specification.",

author = "D. Cook and P. Genever",

year = "2013",

month = apr,

day = "24",

doi = "10.1007/978-94-007-6621-1_12",

language = "English",

volume = "786",

pages = "213--229",

journal = "Advances in experimental medicine and biology",

issn = "0065-2598",

publisher = "Springer",

}

TY - JOUR

T1 - Regulation of mesenchymal stem cell differentiation.

AU - Cook, D.

AU - Genever, P.

PY - 2013/4/24

Y1 - 2013/4/24

N2 - A population of multipotent stromal cells exists within bone marrow and other adult tissues, which is able to differentiate into different skeletal tissues such as bone, cartilage and fat. These cells are frequently referred to as mesenchymal stem cells (MSCs) and offer significant therapeutic potential, particularly in orthopaedic applications, but may also have broader roles in regenerative medicine, cancer treatment, as anti-inflammatories, immunosuppressives and vehicles for gene/protein therapy. Much attention has focused on understanding MSC biology and the regulation of differentiation to help realise these clinical aspirations. Here we review some of the key molecular determinants of MSC function, with an emphasis on transcription factor control and the cell-cell signalling pathways that regulate MSC differentiation. The source information comes from a range of different models, including isolated human MSC cultures, animal-derived MSC-like cell lines, animal models and skeletal developmental processes to provide a wide-angled overview of the important players in MSC biology and tri-lineage specification.

AB - A population of multipotent stromal cells exists within bone marrow and other adult tissues, which is able to differentiate into different skeletal tissues such as bone, cartilage and fat. These cells are frequently referred to as mesenchymal stem cells (MSCs) and offer significant therapeutic potential, particularly in orthopaedic applications, but may also have broader roles in regenerative medicine, cancer treatment, as anti-inflammatories, immunosuppressives and vehicles for gene/protein therapy. Much attention has focused on understanding MSC biology and the regulation of differentiation to help realise these clinical aspirations. Here we review some of the key molecular determinants of MSC function, with an emphasis on transcription factor control and the cell-cell signalling pathways that regulate MSC differentiation. The source information comes from a range of different models, including isolated human MSC cultures, animal-derived MSC-like cell lines, animal models and skeletal developmental processes to provide a wide-angled overview of the important players in MSC biology and tri-lineage specification.

UR - http://www.scopus.com/inward/record.url?scp=84884188210&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-6621-1_12

DO - 10.1007/978-94-007-6621-1_12

M3 - Article

SN - 0065-2598

VL - 786

SP - 213

EP - 229

JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Regulation of mesenchymal stem cell differentiation.

Abstract

Access to Document

Other files and links

Cite this