Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

Peter J. Rayner; Ben J. Tickner; Wissam Iali; Marianna Fekete; Alastair D. Robinson; Simon B. Duckett

doi:10.1039/C9SC02765C

Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

Peter J. Rayner, Ben J. Tickner, Wissam Iali, Marianna Fekete, Alastair D. Robinson, Simon B. Duckett^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting ¹H NMR signal gains which subsequently approach 10³ per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

Original language	English
Pages (from-to)	7709-7717
Number of pages	9
Journal	Chemical Science
Volume	10
Issue number	33
Early online date	1 Jul 2019
DOIs	https://doi.org/10.1039/C9SC02765C https://doi.org/10.1039/c9sc02765c
Publication status	Published - 1 Jul 2019

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10.1039/C9SC02765CLicence: CC BY
10.1039/c9sc02765cLicence: CC BY

ChemSciAlchohols12Accepted author manuscript, 4.78 MBLicence: Unspecified
c9sc02765c
© The Royal Society of Chemistry 2019.
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AU - Rayner, Peter J.

AU - Tickner, Ben J.

AU - Iali, Wissam

AU - Fekete, Marianna

AU - Robinson, Alastair D.

AU - Duckett, Simon B.

PY - 2019/7/1

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AB - The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

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JO - Chemical Science

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Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

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Hyperpolarisation using SABRE as a new tool for imaging

Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols

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Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

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Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols

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