Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

Peter J. Rayner, Ben J. Tickner, Wissam Iali, Marianna Fekete, Alastair D. Robinson, Simon B. Duckett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

Original languageEnglish
Pages (from-to)7709-7717
Number of pages9
JournalChemical Science
Issue number33
Early online date1 Jul 2019
Publication statusPublished - 1 Jul 2019

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© The Royal Society of Chemistry 2019.

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