Reorganization of human cortical maps caused by inherited photoreceptor abnormalities

Heidi Baseler, Alyissa. A. Brewer, Lindsay. T. Sharpe, Herbert Jägle, Brian. A. Wandell, Antony Morland

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.
Original languageEnglish
Pages (from-to)364-370
Number of pages6
JournalNature neuroscience
Volume5
Issue number4
DOIs
Publication statusPublished - Feb 2002

Keywords

  • Adult
  • Brain Mapping
  • Color Vision Defects
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Retinal Cone Photoreceptor Cells
  • Visual Cortex
  • Visual Fields
  • Visual Pathways
  • Visual Perception

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