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From the same journal

Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis

Research output: Contribution to journalArticle

Author(s)

  • F. Catalá-López
  • L. Caulley
  • M. Ridao
  • B. Hutton
  • D. Husereau
  • M. F. Drummond
  • A. Alonso-Arroyo
  • M. Pardo-Fernández
  • E. Bernal-Delgado
  • R. Meneu
  • R. Tabarés-Seisdedos
  • J. Ramón Repullo
  • D. Moher

Department/unit(s)

Publication details

JournalBMJ Open
DateAccepted/In press - 7 Jan 2020
DatePublished (current) - 14 Feb 2020
Volume10
Number of pages6
Original languageEnglish

Abstract

Introduction There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative
analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of
economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility.
Methods and analysis This is the study protocol for a cross-sectional comparative analysis. We registered the study protocol within the Open Science Framework ( osf.io/gzaxr). We will evaluate a random sample of 600
cost-effectiveness analysis publications, a specific form of health economic evaluations, indexed in MEDLINE during 2012 (n=200), 2019 (n=200) and 2022 (n=200). We will include published papers written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years and/or disability-adjusted life years. Screening and selection of articles will be conducted by at least two researchers. Reproducible research practices, openness and transparency in each article will be extracted using a standardised data extraction form by multiple researchers, with a 33% random sample (n=200) extracted in duplicate.
Information on general, methodological and reproducibility items will be reported, stratified by year, citation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement and journal. Risk ratios
with 95% CIs will be calculated to represent changes in reporting between 2012–2019 and 2019–2022.

Bibliographical note

© Author(s) (or their employer(s)) 2020

    Research areas

  • Cost-effectiveness analysis, Data sharing, Methodology, Quality, Reporting, Reproducibility

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