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Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv

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Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv. / Snajdrova, Radka; Grogan, Gideon; Mihovilovic, Marko D.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 16, No. 18, 15.09.2006, p. 4813-4817.

Research output: Contribution to journalArticlepeer-review

Harvard

Snajdrova, R, Grogan, G & Mihovilovic, MD 2006, 'Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv', Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4813-4817. https://doi.org/10.1016/j.bmcl.2006.06.072

APA

Snajdrova, R., Grogan, G., & Mihovilovic, M. D. (2006). Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv. Bioorganic & Medicinal Chemistry Letters, 16(18), 4813-4817. https://doi.org/10.1016/j.bmcl.2006.06.072

Vancouver

Snajdrova R, Grogan G, Mihovilovic MD. Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv. Bioorganic & Medicinal Chemistry Letters. 2006 Sep 15;16(18):4813-4817. https://doi.org/10.1016/j.bmcl.2006.06.072

Author

Snajdrova, Radka ; Grogan, Gideon ; Mihovilovic, Marko D. / Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv. In: Bioorganic & Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 18. pp. 4813-4817.

Bibtex - Download

@article{015e6c1cf58844188522773da2df62c4,
title = "Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv",
abstract = "Recombinant Escherichia coli B834 (DE3) pDB5 expressing the Rv3049c gene encoding a Baeyer-Villiger monooxygenase from Mycobacterium tuberculosis H37Rv was used for regioselective oxidations of fused bicyclic ketones. This whole-cell system represents the first recombinant Baeyer-Villiger oxidation biocatalyst that effectively resolves the racemic starting materials in this series. Within biotransformations using this organism one substrate enantiomer remains in high optical purity, while the second enantiomer is oxidized to one type of regioisomeric lactone preferably. (c) 2006 Elsevier Ltd. All rights reserved.",
keywords = "Baeyer-Villiger oxidation, biocatalysis, biotransformation, lactone, monooxygenase, ENGINEERED ESCHERICHIA-COLI, MICROBIOLOGICAL TRANSFORMATIONS, WHOLE-CELLS, OXIDATIONS, CLONING, ROUTE",
author = "Radka Snajdrova and Gideon Grogan and Mihovilovic, {Marko D.}",
year = "2006",
month = sep,
day = "15",
doi = "10.1016/j.bmcl.2006.06.072",
language = "English",
volume = "16",
pages = "4813--4817",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "18",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv

AU - Snajdrova, Radka

AU - Grogan, Gideon

AU - Mihovilovic, Marko D.

PY - 2006/9/15

Y1 - 2006/9/15

N2 - Recombinant Escherichia coli B834 (DE3) pDB5 expressing the Rv3049c gene encoding a Baeyer-Villiger monooxygenase from Mycobacterium tuberculosis H37Rv was used for regioselective oxidations of fused bicyclic ketones. This whole-cell system represents the first recombinant Baeyer-Villiger oxidation biocatalyst that effectively resolves the racemic starting materials in this series. Within biotransformations using this organism one substrate enantiomer remains in high optical purity, while the second enantiomer is oxidized to one type of regioisomeric lactone preferably. (c) 2006 Elsevier Ltd. All rights reserved.

AB - Recombinant Escherichia coli B834 (DE3) pDB5 expressing the Rv3049c gene encoding a Baeyer-Villiger monooxygenase from Mycobacterium tuberculosis H37Rv was used for regioselective oxidations of fused bicyclic ketones. This whole-cell system represents the first recombinant Baeyer-Villiger oxidation biocatalyst that effectively resolves the racemic starting materials in this series. Within biotransformations using this organism one substrate enantiomer remains in high optical purity, while the second enantiomer is oxidized to one type of regioisomeric lactone preferably. (c) 2006 Elsevier Ltd. All rights reserved.

KW - Baeyer-Villiger oxidation

KW - biocatalysis

KW - biotransformation

KW - lactone

KW - monooxygenase

KW - ENGINEERED ESCHERICHIA-COLI

KW - MICROBIOLOGICAL TRANSFORMATIONS

KW - WHOLE-CELLS

KW - OXIDATIONS

KW - CLONING

KW - ROUTE

U2 - 10.1016/j.bmcl.2006.06.072

DO - 10.1016/j.bmcl.2006.06.072

M3 - Article

VL - 16

SP - 4813

EP - 4817

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 18

ER -