Retrograde transport on the COG railway

Daniel Ungar; Toshihiko Oka; Monty Krieger; Frederick M Hughson

doi:10.1016/j.tcb.2005.12.004

Retrograde transport on the COG railway

Daniel Ungar, Toshihiko Oka, Monty Krieger, Frederick M Hughson

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.

Original language	English
Pages (from-to)	113-20
Number of pages	8
Journal	TRENDS IN CELL BIOLOGY
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.tcb.2005.12.004
Publication status	Published - 2006

Keywords

Adaptor Proteins, Vesicular Transport
Animals
Biological Transport
Carrier Proteins
Golgi Apparatus
Humans
Models, Biological
Proteins

Access to Document

10.1016/j.tcb.2005.12.004

Cite this

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title = "Retrograde transport on the COG railway",

abstract = "The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.",

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AU - Ungar, Daniel

AU - Oka, Toshihiko

AU - Krieger, Monty

AU - Hughson, Frederick M

PY - 2006

Y1 - 2006

N2 - The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.

AB - The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.

KW - Adaptor Proteins, Vesicular Transport

KW - Animals

KW - Biological Transport

KW - Carrier Proteins

KW - Golgi Apparatus

KW - Humans

KW - Models, Biological

KW - Proteins

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DO - 10.1016/j.tcb.2005.12.004

M3 - Article

C2 - 16406524

SN - 0962-8924

VL - 16

SP - 113

EP - 120

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

IS - 2

ER -