Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments

Yilian Fernández-Afonso; Sergiu Ruta; Amira Páez-Rodríguez; Thomas S. van Zanten; Sian Gleadhall; Raluca M. Fratila; María Moros; Maria del Puerto Morales; Akira Satoh; Roy W. Chantrell; David Serantes; Lucía Gutiérrez

doi:10.1002/adfm.202405334

Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments

Yilian Fernández-Afonso, Sergiu Ruta, Amira Páez-Rodríguez, Thomas S. van Zanten, Sian Gleadhall, Raluca M. Fratila, María Moros, Maria del Puerto Morales, Akira Satoh, Roy W. Chantrell, David Serantes^*, Lucía Gutiérrez^*

^*Corresponding author for this work

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field-driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.

Original language	English
Article number	2405334
Number of pages	15
Journal	ADVANCED FUNCTIONAL MATERIALS
Early online date	15 Jul 2024
DOIs	https://doi.org/10.1002/adfm.202405334
Publication status	E-pub ahead of print - 15 Jul 2024

Bibliographical note

Keywords

assembly
brownian dynamics
colloids
in vitro
kinetic monte-carlo
magnetic nanoparticles

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Adv Funct Materials - 2024 - Fernández‐Afonso - Reversible Alignment of Nanoparticles and Intracellular Vesicles During
© 2024 The Author(s).
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Fernández-Afonso, Y., Ruta, S., Páez-Rodríguez, A., van Zanten, T. S., Gleadhall, S., Fratila, R. M., Moros, M., Morales, M. D. P., Satoh, A., Chantrell, R. W., Serantes, D., & Gutiérrez, L. (2024). Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments. ADVANCED FUNCTIONAL MATERIALS, Article 2405334. Advance online publication. https://doi.org/10.1002/adfm.202405334

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abstract = "Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field-driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.",

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AU - Fernández-Afonso, Yilian

AU - Ruta, Sergiu

AU - Páez-Rodríguez, Amira

AU - van Zanten, Thomas S.

AU - Gleadhall, Sian

AU - Fratila, Raluca M.

AU - Moros, María

AU - Morales, Maria del Puerto

AU - Satoh, Akira

AU - Chantrell, Roy W.

AU - Serantes, David

AU - Gutiérrez, Lucía

PY - 2024/7/15

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N2 - Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field-driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.

AB - Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field-driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.

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Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments

Abstract

Bibliographical note

Keywords

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