Ring Expansion Homologation: Synthetic Strategies and Reaction Design

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter concerns the application and design of homologation strategies to cyclic molecules in order to effect overall ring expansion. The importance of ring size in ring expansion homologation reactions is a major theme in this chapter. The chapter starts with a discussion of the key features of reactions that require specific ring sizes in order to proceed effectively. Next, reactions that operate on multiple ring sizes are covered. In view of the importance of ring expansion homologation procedures for the preparation of synthetically challenging medium-sized rings and macrocycles, methods that facilitate access to these larger ringed systems are then described. Finally, strategies that allow the rings to be “grown” to a greater degree via iterative homologation and/or higher homologation reactions are discussed.

Original languageEnglish
Title of host publicationHomologation Reactions
Subtitle of host publicationReagents, Applications, and Mechanisms
PublisherWiley-Blackwell Publishing Ltd
Number of pages14
ISBN (Electronic)9783527830237
ISBN (Print)9783527351244
Publication statusPublished - 26 May 2023

Bibliographical note

Publisher Copyright:
© 2023 WILEY-VCH GmbH.


  • Homologation
  • Macrocycle
  • Medium-sized ring
  • Rearrangement
  • Ring enlargement
  • Ring expansion

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