Research output: Contribution to journal › Review article › peer-review
CEJ SuRE medium ring paper accepted article manuscript
1.36 MB, Word document
Journal | Chemistry : A European Journal |
---|---|
Date | Accepted/In press - 6 Mar 2017 |
Date | Published (current) - 15 Mar 2017 |
Volume | 23 |
Number of pages | 20 |
Pages (from-to) | 8780-8799 |
Original language | English |
Functionalised macrocycles and medium-sized rings have applications in a number of scientific fields, ranging from medicinal chemistry and supramolecular chemistry, to catalysis and nanotechnology. However, their value in these areas can be undermined by a simple, but important limitation: large ring systems are very often difficult to make. Traditional end-to-end cyclisation reactions of long linear precursors are typically unpredictable and impractical processes, mainly due to unfavourable enthalpic and entropic factors. Most published methods to make large rings focus on minimising the damage inflicted by performing the difficult cyclisation step; in contrast, ring expansion reactions enable it to be avoided altogether. In this review, we seek to highlight how 'growing' rings from existing cyclic systems via ring expansion can expedite the efficient, practical and scalable synthesis of macrocycles and medium-sized rings.
This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Activity: Talk or presentation › Invited talk
Find related publications, people, projects, datasets and more using interactive charts.