Ring expansion reactions of P=O-containing molecules

Zhongzhen Yang, Jerry K F Tam, Jack M Wootton, Jason M Lynam, William P Unsworth

Research output: Contribution to journalArticlepeer-review


A series of ring expansion reactions of P=O-containing molecules have been developed for the synthesis of medium-sized ring cyclic phosphonate esters and phosphonamidates. The reactivity trends initially appear to be counter-intuitive, compared with more well established ring expansion reactions of lactam derivatives, but are explained by considering the differences in heteroatom bonding to P and C respectively.

Original languageEnglish
Number of pages4
JournalChemical communications
Early online date30 May 2023
Publication statusE-pub ahead of print - 30 May 2023

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© The Royal Society of Chemistry 2023

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