Ring expansion reactions of P=O-containing molecules

Zhongzhen Yang; Jerry K F Tam; Jack M Wootton; Jason M Lynam; William P Unsworth

doi:10.1039/d3cc02087h

Ring expansion reactions of P=O-containing molecules

Zhongzhen Yang, Jerry K F Tam, Jack M Wootton, Jason M Lynam, William P Unsworth

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of ring expansion reactions of P=O-containing molecules have been developed for the synthesis of medium-sized ring cyclic phosphonate esters and phosphonamidates. The reactivity trends initially appear to be counter-intuitive, compared with more well established ring expansion reactions of lactam derivatives, but are explained by considering the differences in heteroatom bonding to P and C respectively.

Original language	English
Number of pages	4
Journal	Chemical communications
Early online date	30 May 2023
DOIs	https://doi.org/10.1039/d3cc02087h
Publication status	E-pub ahead of print - 30 May 2023

Bibliographical note

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10.1039/d3cc02087hLicence: CC BY-NC

d3cc02087h
© The Royal Society of Chemistry 2023
Final published version, 1.21 MBLicence: CC BY-NC

Cite this

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title = "Ring expansion reactions of P=O-containing molecules",

abstract = "A series of ring expansion reactions of P=O-containing molecules have been developed for the synthesis of medium-sized ring cyclic phosphonate esters and phosphonamidates. The reactivity trends initially appear to be counter-intuitive, compared with more well established ring expansion reactions of lactam derivatives, but are explained by considering the differences in heteroatom bonding to P and C respectively.",

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AU - Yang, Zhongzhen

AU - Tam, Jerry K F

AU - Wootton, Jack M

AU - Lynam, Jason M

AU - Unsworth, William P

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AB - A series of ring expansion reactions of P=O-containing molecules have been developed for the synthesis of medium-sized ring cyclic phosphonate esters and phosphonamidates. The reactivity trends initially appear to be counter-intuitive, compared with more well established ring expansion reactions of lactam derivatives, but are explained by considering the differences in heteroatom bonding to P and C respectively.

U2 - 10.1039/d3cc02087h

DO - 10.1039/d3cc02087h

M3 - Article

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