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Risk factors for fracture in a UK population: a prospective cohort study

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JournalQJM Monthly Journal of the Association of Physicians
DatePublished - Sep 2004
Issue number9
Volume97
Number of pages6
Pages (from-to)569-574
Original languageEnglish

Abstract

Background: Common clinical risk factors for fracture in older women have been identified. To date, most of these risk factors have not been confirmed in a UK population.

Aim: To confirm the important risk factors for fracture in older women.

Design: Comprehensive cohort study (CCS) with a nested randomized controlled trial.

Methods: The CCS included 4292 women aged >70 years. We assessed potential risk factors for fracture, and followed-up participants for 24 months for incidence of non-vertebral fractures.

Results: Odds ratios (ORs) for predicting any nonvertebral fracture were: previous fracture, 2.67 (95%Cl 2.10-3.40); a fall in the last 12 months, 2.06 (95% CI 1.63-2.59); and age (per year increase), 1.03 (95% CI 1.01-1.05). ORs for predicting hip fracture were: previous fracture, 2.31 (95% CI 1.31-4.08); low body weight (<58 kg), 2.20 (95% CI 1.28-3.77); maternal history of hip fracture, 1.68 (95% CI 0.85-3.31); a fall in the last 12 months, 2.92 (95% CI 1.70-5.01); and age (per year increase), 1.09 (95% CI 1.04-1.13). ORs for predicting wrist fracture were: previous fracture, 2.29 (95% CI 1.56-3.34); and a fall in the last 12 months, 1.60 (95% CI 1.10-2.31). Being a current smoker was not associated with an increase in risk, and was consistent across all fracture types.

Discussion: Older women with the clinical risk factors identified in this study should be investigated for osteoporosis or offered preventive treatment.

    Research areas

  • BONE-MINERAL DENSITY, ELDERLY WOMEN, HIP FRACTURE, OSTEOPOROTIC FRACTURES, SELF-REPORT, WRIST FRACTURES, METAANALYSIS, VALIDITY, SMOKING, EPIDOS

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