Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda

Katie Wakeham, Emily L Webb, Ismail Sebina, Angela Nalwoga, Lawrence Muhangi, Wendell Miley, W Thomas Johnston, Juliet Ndibazza, Denise Whitby, Robert Newton, Alison M Elliott

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BACKGROUND:: Determinants of Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a well-characterised birth cohort we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95% confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.
Original languageEnglish
Pages (from-to)228-233
JournalJournal of acquired immune deficiency syndromes (1999)
Issue number2
Publication statusPublished - 1 Jun 2013

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