Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda

Katie Wakeham; Emily L Webb; Ismail Sebina; Angela Nalwoga; Lawrence Muhangi; Wendell Miley; W Thomas Johnston; Juliet Ndibazza; Denise Whitby; Robert Newton; Alison M Elliott

doi:10.1097/QAI.0b013e31828a7056

Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda

Katie Wakeham, Emily L Webb, Ismail Sebina, Angela Nalwoga, Lawrence Muhangi, Wendell Miley, W Thomas Johnston, Juliet Ndibazza, Denise Whitby, Robert Newton, Alison M Elliott

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND:: Determinants of Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a well-characterised birth cohort we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95% confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.

Original language	English
Pages (from-to)	228-233
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	63
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e31828a7056
Publication status	Published - 1 Jun 2013

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10.1097/QAI.0b013e31828a7056

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Wakeham, K., Webb, E. L., Sebina, I., Nalwoga, A., Muhangi, L., Miley, W., Johnston, W. T., Ndibazza, J., Whitby, D., Newton, R., & Elliott, A. M. (2013). Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda. Journal of acquired immune deficiency syndromes (1999), 63(2), 228-233. https://doi.org/10.1097/QAI.0b013e31828a7056

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title = "Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda",

abstract = "BACKGROUND:: Determinants of Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a well-characterised birth cohort we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95% confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.",

author = "Katie Wakeham and Webb, {Emily L} and Ismail Sebina and Angela Nalwoga and Lawrence Muhangi and Wendell Miley and Johnston, {W Thomas} and Juliet Ndibazza and Denise Whitby and Robert Newton and Elliott, {Alison M}",

year = "2013",

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doi = "10.1097/QAI.0b013e31828a7056",

language = "English",

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Wakeham, K, Webb, EL, Sebina, I, Nalwoga, A, Muhangi, L, Miley, W, Johnston, WT, Ndibazza, J, Whitby, D, Newton, R & Elliott, AM 2013, 'Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda', Journal of acquired immune deficiency syndromes (1999), vol. 63, no. 2, pp. 228-233. https://doi.org/10.1097/QAI.0b013e31828a7056

TY - JOUR

T1 - Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda

AU - Wakeham, Katie

AU - Webb, Emily L

AU - Sebina, Ismail

AU - Nalwoga, Angela

AU - Muhangi, Lawrence

AU - Miley, Wendell

AU - Johnston, W Thomas

AU - Ndibazza, Juliet

AU - Whitby, Denise

AU - Newton, Robert

AU - Elliott, Alison M

PY - 2013/6/1

Y1 - 2013/6/1

N2 - BACKGROUND:: Determinants of Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a well-characterised birth cohort we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95% confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.

AB - BACKGROUND:: Determinants of Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic, are not well understood. Local environmental factors, including other infectious agents, may be key. METHODS:: Within the context of a well-characterised birth cohort we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda. RESULTS:: Seroprevalence increased with increasing age of the child (p=0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs. 9%; odds ratio (OR) 1.4, 95% confidence interval (CI) 1.1-2.0). It was also higher among children with HIV infection (29% vs. 10%; OR 3.1, 95% CI 1.2-8.3) or malaria parasitaemia (30% vs 10%; OR 4.1, 95% CI 2.4-7.0), than in children without. These associations were not explained by socioeconomic status. CONCLUSION:: The finding that KSHV serostatus is associated with malaria parasitaemia in children is novel. In a country endemic for KSHV, malaria may be a co-factor for KSHV infection or reactivation among children.

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U2 - 10.1097/QAI.0b013e31828a7056

DO - 10.1097/QAI.0b013e31828a7056

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C2 - 23403859

SN - 1944-7884

VL - 63

SP - 228

EP - 233

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

IS - 2

ER -

Risk factors for seropositivity to Kaposi's sarcoma associated herpesvirus (KSHV) among children in Uganda

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