TY - JOUR
T1 - RNA polymerases I and III, non-coding RNAs and cancer
AU - White, R.J.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Oncogenically transformed cells overexpress the non-coding RNAs, such as pre-ribosomal RNA (rRNA) and transfer RNA (tRNA), which are produced by RNA polymerases (Pols) I and III. Recent results indicate that levels of pre-rRNA have prognostic value and that a tRNA has oncogenic potential. Transcription by Pols I and III is restrained in healthy cells by the tumour suppressors RB, p53, ARF and PTEN. Such restraints are compromised during cell transformation and the problem is accentuated by oncogene products, such as c-Myc, that stimulate the output of Pol I and Pol III. The resultant increases in rRNA and tRNA expression might promote the generation of cancers.
AB - Oncogenically transformed cells overexpress the non-coding RNAs, such as pre-ribosomal RNA (rRNA) and transfer RNA (tRNA), which are produced by RNA polymerases (Pols) I and III. Recent results indicate that levels of pre-rRNA have prognostic value and that a tRNA has oncogenic potential. Transcription by Pols I and III is restrained in healthy cells by the tumour suppressors RB, p53, ARF and PTEN. Such restraints are compromised during cell transformation and the problem is accentuated by oncogene products, such as c-Myc, that stimulate the output of Pol I and Pol III. The resultant increases in rRNA and tRNA expression might promote the generation of cancers.
UR - http://www.scopus.com/inward/record.url?scp=56649105133&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2008.10.003
DO - 10.1016/j.tig.2008.10.003
M3 - Article
AN - SCOPUS:56649105133
SN - 0168-9525
VL - 24
SP - 622
EP - 629
JO - Trends in Genetics
JF - Trends in Genetics
IS - 12
ER -