Roles for glutathione transferases in antioxidant recycling.

Robert Edwards, Dixon, D.P, Steel, P.G

Research output: Contribution to journalArticlepeer-review


Uniquely among the plant glutathione transferases, two classes possess a catalytic cysteine capable of performing glutathione-dependent reductions. These are the dehydroascorbate reductases (DHARs) and the lambda-class glutathione transferases (GSTLs). Using immobilized GSTLs probed with crude plant extracts we have identified flavonols as high affinity ligands and subsequently demonstrated a novel glutathione-dependent role for these enzymes in recycling oxidized quercetin. By comparing the activities of DHARs and GSTLs we now propose a unified catalytic mechanism that suggests oxidized anthocyanidins and tocopherols may be alternative polyphenolic substrates of GSTLs.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalPlant Signaling and Behavior
Issue number8
Publication statusPublished - Aug 2011

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