ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging

G. Snieckute; L. Ryder; A. C. Vind; Z. Wu; F. S. Arendrup; M. Stoneley; S. Chamois; A. Martinez-Val; M. Leleu; Rene Dreos; A. Russell; D. M.  Gay; Aitana V Genzor; B.S. Choi; A. L.  Basse; F. Sass; M. Dall; L. C. M.  Dollet; M. Blasius; A. E. Willis; A Lund; J. T. Treebak; Jesper Olsen; S. S. Poulsen; Betsy Pownall; Bente Jensen; C. Clemmensen; Z. Gerhart-Zines; D. Gatfield; Simon Bekker-Jensen

doi:10.1126/science.adf3208

ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging

G. Snieckute, L. Ryder, A. C. Vind, Z. Wu, F. S. Arendrup, M. Stoneley, S. Chamois, A. Martinez-Val, M. Leleu, Rene Dreos, A. Russell, D. M. Gay, Aitana V Genzor, B.S. Choi, A. L. Basse, F. Sass, M. Dall, L. C. M. Dollet, M. Blasius, A. E. WillisA Lund, J. T. Treebak, Jesper Olsen, S. S. Poulsen, Betsy Pownall, Bente Jensen, C. Clemmensen, Z. Gerhart-Zines, D. Gatfield, Simon Bekker-Jensen

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1135
Number of pages	15
Journal	Science
Volume	382
Issue number	6675
Early online date	8 Dec 2023
DOIs	https://doi.org/10.1126/science.adf3208
Publication status	Published - 8 Dec 2023

Bibliographical note

This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.

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10.1126/science.adf3208

Snieckute et al 2023
This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.
Accepted author manuscript, 12.7 MBLicence: CC BY

Cite this

Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., ... Bekker-Jensen, S. (2023). ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging. Science, 382(6675), Article 1135. https://doi.org/10.1126/science.adf3208

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title = "ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging",

author = "G. Snieckute and L. Ryder and Vind, {A. C.} and Z. Wu and Arendrup, {F. S.} and M. Stoneley and S. Chamois and A. Martinez-Val and M. Leleu and Rene Dreos and A. Russell and Gay, {D. M.} and Genzor, {Aitana V} and B.S. Choi and Basse, {A. L.} and F. Sass and M. Dall and Dollet, {L. C. M.} and M. Blasius and Willis, {A. E.} and A Lund and Treebak, {J. T.} and Jesper Olsen and Poulsen, {S. S.} and Betsy Pownall and Bente Jensen and C. Clemmensen and Z. Gerhart-Zines and D. Gatfield and Simon Bekker-Jensen",

note = "This is an author-produced version of the published paper. Uploaded in accordance with the University{\textquoteright}s Research Publications and Open Access policy. ",

year = "2023",

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Snieckute, G, Ryder, L, Vind, AC, Wu, Z, Arendrup, FS, Stoneley, M, Chamois, S, Martinez-Val, A, Leleu, M, Dreos, R, Russell, A, Gay, DM, Genzor, AV, Choi, BS, Basse, AL, Sass, F, Dall, M, Dollet, LCM, Blasius, M, Willis, AE, Lund, A, Treebak, JT, Olsen, J, Poulsen, SS, Pownall, B, Jensen, B, Clemmensen, C, Gerhart-Zines, Z, Gatfield, D & Bekker-Jensen, S 2023, 'ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging', Science, vol. 382, no. 6675, 1135. https://doi.org/10.1126/science.adf3208

TY - JOUR

T1 - ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging

AU - Snieckute, G.

AU - Ryder, L.

AU - Vind, A. C.

AU - Wu, Z.

AU - Arendrup, F. S.

AU - Stoneley, M.

AU - Chamois, S.

AU - Martinez-Val, A.

AU - Leleu, M.

AU - Dreos, Rene

AU - Russell, A.

AU - Gay, D. M.

AU - Genzor, Aitana V

AU - Choi, B.S.

AU - Basse, A. L.

AU - Sass, F.

AU - Dall, M.

AU - Dollet, L. C. M.

AU - Blasius, M.

AU - Willis, A. E.

AU - Lund, A

AU - Treebak, J. T.

AU - Olsen, Jesper

AU - Poulsen, S. S.

AU - Pownall, Betsy

AU - Jensen, Bente

AU - Clemmensen, C.

AU - Gerhart-Zines, Z.

AU - Gatfield, D.

AU - Bekker-Jensen, Simon

N1 - This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.

PY - 2023/12/8

Y1 - 2023/12/8

U2 - 10.1126/science.adf3208

DO - 10.1126/science.adf3208

M3 - Article

SN - 0036-8075

VL - 382

JO - Science

JF - Science

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