Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial

DART Trial Team

Research output: Contribution to journalArticlepeer-review

Abstract

HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa.
Original languageEnglish
Pages (from-to)123-31
Number of pages9
JournalLancet.
Volume375
Issue number9709
DOIs
Publication statusPublished - 9 Jan 2010

Bibliographical note

Copyright 2010 Elsevier Ltd. All rights reserved.

Keywords

  • Humans
  • Disease Progression
  • Zidovudine
  • Aged
  • Lamivudine
  • Urea
  • Dideoxynucleosides
  • CD4 Lymphocyte Count
  • HIV-1
  • Anti-Retroviral Agents
  • Hemoglobins
  • Neutrophils
  • Drug Monitoring
  • Adult
  • Adenine
  • Adolescent
  • Male
  • Anemia
  • RNA, Viral
  • Viral Load
  • Neutropenia
  • Nevirapine
  • Organophosphonates
  • Creatinine
  • HIV-Associated Lipodystrophy Syndrome
  • Glomerular Filtration Rate
  • HIV Infections
  • Africa
  • Middle Aged
  • Female

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