Running an IPD Meta-Analysis Project: From Developing the Protocol to Preparing Data for Meta-Analysis

Jayne F. Tierney, Richard D. Riley, Larysa H.M. Rydzewska, Lesley A. Stewart

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter provides guidance on the preparations needed just prior to the collection of individual participant data (IPD) and how to go about establishing and maintaining collaboration with IPD providers. It discusses various aspects that should be considered when preparing to collect IPD. Negotiating and maintaining collaborations with trial investigators and organisations from different countries, settings and disciplines can take considerable time and effort, and requires careful management, but is critical to the success of collaborative IPD meta-analysis projects. A data-sharing agreement outlining the nature of the collaboration, the responsibilities and obligations of each party, and intellectual property arrangements will be supplied with the finalised protocol. The checking and harmonisation of IPD across trials are integral and necessary components of an IPD meta-analysis project. The results of validity checking and risk of bias assessment should be considered together in order to build up an overall picture of the quality of each trial's IPD.

Original languageEnglish
Title of host publicationIndividual Participant Data Meta-Analysis
Subtitle of host publicationa Handbook for Healthcare Research
PublisherWiley-Blackwell Publishing Ltd
Number of pages36
ISBN (Electronic)9781119333784
ISBN (Print)9781119333722
Publication statusPublished - 22 Apr 2021

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