SABRE-Relay: A Versatile Route to Hyperpolarization

Soumya S. Roy, Kate M. Appleby, Elizabeth J. Fear, Simon B. Duckett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H2) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine and pyrazine). The substrate then reacts reversibly with [Pt(OTf)2(bis-diphenylphosphinopropane)] by displacing OTf- to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The 31P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding 31P signal was 105 ± 8 times larger than expected, which equated to an 8-hour reduction in total scan time for an equivalent signal to noise ratio under normal acquisition conditions. Hence p-H2 derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrate that are not amenable to normal SABRE.
Original languageEnglish
Article numberjz-2017-03026f.R3
Pages (from-to)1112-1117
Number of pages6
Issue number5
Early online date12 Feb 2018
Publication statusPublished - 1 Mar 2018

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