Abstract
Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.
| Original language | English |
|---|---|
| Pages (from-to) | 38-43 |
| Number of pages | 6 |
| Journal | Molecular immunology |
| Volume | 86 |
| Early online date | 11 Dec 2016 |
| DOIs | |
| Publication status | E-pub ahead of print - 11 Dec 2016 |
Bibliographical note
Copyright © 2016 Elsevier Ltd. All rights reserved.Keywords
- Animals
- Caspases/metabolism
- Host-Pathogen Interactions/immunology
- Humans
- Immunity, Innate
- Inflammasomes/immunology
- Interleukin-18/metabolism
- Interleukin-1beta/metabolism
- Intestinal Mucosa/immunology
- Macrophages/immunology
- Mice
- NLR Proteins/metabolism
- Pathogen-Associated Molecular Pattern Molecules/immunology
- Pyroptosis
- Salmonella Infections/immunology
- Salmonella typhimurium/immunology
- Signal Transduction
- Toll-Like Receptors/metabolism