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Salmonella-induced inflammasome activation in humans

Research output: Contribution to journalReview articlepeer-review

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Publication details

JournalMolecular immunology
DateAccepted/In press - 17 Nov 2016
DateE-pub ahead of print (current) - 11 Dec 2016
Volume86
Number of pages6
Pages (from-to)38-43
Early online date11/12/16
Original languageEnglish

Abstract

Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.

Bibliographical note

Copyright © 2016 Elsevier Ltd. All rights reserved.

    Research areas

  • Animals, Caspases/metabolism, Host-Pathogen Interactions/immunology, Humans, Immunity, Innate, Inflammasomes/immunology, Interleukin-18/metabolism, Interleukin-1beta/metabolism, Intestinal Mucosa/immunology, Macrophages/immunology, Mice, NLR Proteins/metabolism, Pathogen-Associated Molecular Pattern Molecules/immunology, Pyroptosis, Salmonella Infections/immunology, Salmonella typhimurium/immunology, Signal Transduction, Toll-Like Receptors/metabolism

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