Abstract
Infection of the human host by schistosome parasites follows exposure of skin to free-swimming cercariae and is aided by the release of excretory/secretory (E/S) material which is rich in proteases and glycoconjugates. This material provides the initial stimulus to cells of the innate immune system. The study presented here is the first to examine human innate/early immune responsiveness to cercarial E/S in subjects from an area co-endemic for Schistosoma mansoni and S. haematobium. We report that in infected participants stimulation of whole blood cultures with cercarial E/S material (termed 0-3hRP) caused the early (within 24 hours) release of greater quantities of regulatory IL-10, compared to un-infected controls. Elevated levels of IL-10 but not pro-inflammatory TNFα or IL-8 were most evident in participants co-infected with S. mansoni and S. haematobium and was accompanied by a higher 0-3hRP-specific IL-10: TNFα ratio. We also report that glycosylated components within 0-3hRP appear to be important factors in the stimulation of IL-8, TNFα and IL-10 production by whole blood cells. © 2013 Blackwell Publishing Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 147-156 |
| Number of pages | 10 |
| Journal | Parasite immunology |
| Volume | 35 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 12 Feb 2013 |