Science-based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operations

Joan Tell; Daniel J. Caldwell; Andreas Häner; Jutta Hellstern; Birgit Hoeger; Romain Journel; Frank Mastrocco; Jim J. Ryan; Jason Snape; Jürg Oliver Straub; Jessica Vestel

doi:10.1002/ieam.4141

Science-based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operations

Joan Tell^*, Daniel J. Caldwell, Andreas Häner, Jutta Hellstern, Birgit Hoeger, Romain Journel, Frank Mastrocco, Jim J. Ryan, Jason Snape, Jürg Oliver Straub, Jessica Vestel

^*Corresponding author for this work

Environment and Geography

Research output: Contribution to journal › Article › peer-review

Abstract

In 2016, the United Nations declared the need for urgent action to combat the global threat of antimicrobial resistance (AMR). In support of this effort, the pharmaceutical industry has committed to measures aimed at improving the stewardship of antibiotics both within and outside the clinic. Notably, a group of companies collaborated to specifically address concerns related to antibiotic residues being discharged from manufacturing sites. In addition to developing a framework of minimum environmental expectations for antibiotic manufacturers, science-based receiving water targets were established for antibiotics discharged from manufacturing operations. This paper summarizes the holistic approach taken to derive these targets and includes previously unpublished, company-generated, environmental toxicity data.

Original language	English
Pages (from-to)	312-319
Number of pages	8
Journal	Integrated Environmental Assessment and Management
Volume	15
Issue number	3
DOIs	https://doi.org/10.1002/ieam.4141
Publication status	Published - May 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors

Keywords

Antibiotic
Antibiotic resistance
Antimicrobial resistance (AMR)
Pharmaceutical resistance
PNEC

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10.1002/ieam.4141

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abstract = "In 2016, the United Nations declared the need for urgent action to combat the global threat of antimicrobial resistance (AMR). In support of this effort, the pharmaceutical industry has committed to measures aimed at improving the stewardship of antibiotics both within and outside the clinic. Notably, a group of companies collaborated to specifically address concerns related to antibiotic residues being discharged from manufacturing sites. In addition to developing a framework of minimum environmental expectations for antibiotic manufacturers, science-based receiving water targets were established for antibiotics discharged from manufacturing operations. This paper summarizes the holistic approach taken to derive these targets and includes previously unpublished, company-generated, environmental toxicity data.",

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AU - Journel, Romain

AU - Mastrocco, Frank

AU - Ryan, Jim J.

AU - Snape, Jason

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Science-based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operations

Abstract

Bibliographical note

Keywords

Access to Document

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