Search research publications and outputs

  1. A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.

    Dahlin, JS., Hamey, FK., Pijuan-Sala, B., Shepherd, M. S., Lau, WWY., Nestorowa, S., Weinreb, C., Wolock, S., Hannah, R., Diamanti, E., Kent, DG., Göttgens, B. & Wilson, NK., 24 May 2018

    Article in Blood

  2. A track of the clones: new developments in cellular barcoding.

    Lyne, A-M., Kent, DG., Laurenti, E., Cornils, K., Glauche, I. & Perié, L., 1 Dec 2018

    Article in Experimental hematology

  3. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

    Boucher, D., Monteleone, M., Coll, R. C., Chen, K. W., Ross, C. M., Teo, J. L., Gomez, G. A., Holley, C. L., Bierschenk, D., Stacey, K. J., Yap, A. S., Bezbradica, J. S. & Schroder, K., 5 Mar 2018

    Article in The Journal of experimental medicine

  4. Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion

    Chen, K. W., Lawlor, K. E., von Pein, J. B., Boucher, D., Gerlic, M., Croker, B. A., Bezbradica, J. S., Vince, J. E. & Schroder, K., 15 May 2018

    Article in Journal of Immunology

  5. Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

    Elf, S., Abdelfattah, N. S., Baral, A. J., Rivera, J., Chen, E. & Mullaly, A., 15 Feb 2018

    Article in Blood

  6. HSP90 contributes to entrainment of the Arabidopsis circadian clock via the morning loop

    Davis, A. M., Ronald, J. A., Ma, Z., Wilkinson, A. J., Philippou, K., Shindo, T., Queitsch, C. & Davis, S. J., 1 Dec 2018

    Article in Genetics

  7. Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

    Haider, A. J., Cox, M. H., Jones, N., Goode, A. J., Bridge, K. S., Wong, K., Briggs, D. & Kerr, I. D., 1 Aug 2018

    Article in Bioscience Reports

  8. KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

    Polson, ES., Kuchler, VB., Abbosh, C., Ross, EM., Mathew, RK., Beard, HA., da Silva, B., Holding, AN., Ballereau, S., Chuntharpursat-Bon, E., Williams, J., Griffiths, HBS., Shao, H., Patel, A., Davies, AJ., Droop, A., Chumas, P., Short, SC., Lorger, M., Gestwicki, JE. & 6 others, Roberts, LD., Bon, RS., Allison, SJ., Zhu, S., Markowetz, F. & Wurdak, H., 15 Aug 2018

    Article in Science Translational Medicine

  9. Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.

    Li, J., Prins, D., Park, HJ., Grinfeld, J., Gonzalez-Arias, C., Loughran, S., Dovey, OM., Klampfl, T., Bennett, C., Hamilton, TL., Pask, DC., Sneade, R., Williams, M., Aungier, J., Ghevaert, C., Vassiliou, GS., Kent, DG. & Green, AR., 8 Feb 2018

    Article in Blood

  10. Niche Heterogeneity Impacts Evolution of Myeloproliferative Neoplasms Driven By the Same Oncogenic Pathway

    Korn, C., Rak, J., Garcia-Garcia, A., Fielding, C., Khorshed, R., Gonzalez-Anton, S., Li, J., Norfo, R., Baxter, EJ., McKerrell, T., Roberts, T., Eldaly, H., Godfrey, AL., Castillo-Venzor, A., Kusumbe, A., Mead, AJ., Green, AR., Kent, D., Lo Celso, C. & Mendez-Ferrer, S., 29 Nov 2018

    Article in Blood

  11. Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps

    Chen, K. W., Monteleone, M., Boucher, D., Sollberger, G., Ramnath, D., Condon, N. D., von Pein, J. B., Broz, P., Sweet, M. J. & Schroder, K., 24 Aug 2018

    Article in Science Immunology

  12. Population dynamics of normal human blood inferred from somatic mutations

    Lee-Six, H., Øbro, NF., Shepherd, MS., Grossmann, S., Dawson, K., Belmonte, M., Osborne, RJ., Huntly, BJP., Martincorena, I., Anderson, E., O'Neill, L., Stratton, MR., Laurenti, E., Green, AR., Kent, DG. & Campbell, PJ., 27 Sep 2018

    Article in Nature

  13. Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.

    Shepherd, MS., Li, J., Wilson, NK., Oedekoven, CA., Li, J., Belmonte, M., Fink, J., Prick, JCM., Pask, DC., Hamilton, TL., Loeffler, D., Rao, A., Schröder, T., Göttgens, B., Green, AR. & Kent, DG., 23 Aug 2018

    Article in Blood

  14. Single-cell reconstruction of the early maternal-fetal interface in humans.

    Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J-E., Stephenson, E., Polański, K., Goncalves, A., Gardner, L., Holmqvist, S., Henriksson, J., Zou, A., Sharkey, A. M., Millar, B., Innes, B., Wood, L., Wilbrey-Clark, A., Payne, R. P. & 10 others, Ivarsson, M. A., Lisgo, S., Filby, A., Rowitch, D. H., Bulmer, J. N., Wright, G. J., Stubbington, M. J. T., Haniffa, M., Moffett, A. & Teichmann, S. A., 14 Nov 2018

    Article in Nature